Verma Nikhil, Fazioli Alex, Matijasich Paige
Essential Sports & Spine Solutions, 6100 East Main Street 107, Columbus, OH 43213, USA.
Lake Erie College of Osteopathic Medicine, Erie, PA 16509, USA.
Regen Med. 2022 Apr;17(4):233-244. doi: 10.2217/rme-2021-0084. Epub 2022 Feb 21.
The diagnosis and management of CNS injuries comprises a large portion of psychiatric practice. Many clinical and preclinical studies have demonstrated the benefit of treating CNS injuries using various regenerative techniques and materials such as stem cells, biomaterials and genetic modification. Therefore it is the goal of this review article to briefly summarize the pathogenesis of CNS injuries, including traumatic brain injuries, spinal cord injuries and cerebrovascular accidents. Next, we discuss the role of natural recovery and regeneration of the CNS, explore the relevance in clinical practice and discuss emerging and cutting-edge treatments and current barriers in the field of regenerative medicine.
中枢神经系统损伤的诊断与管理在精神病学实践中占很大一部分。许多临床和临床前研究已证明使用各种再生技术和材料(如干细胞、生物材料和基因修饰)治疗中枢神经系统损伤的益处。因此,本文的目的是简要总结中枢神经系统损伤的发病机制,包括创伤性脑损伤、脊髓损伤和脑血管意外。接下来,我们将讨论中枢神经系统自然恢复和再生的作用,探讨其在临床实践中的相关性,并讨论再生医学领域新兴的前沿治疗方法和当前的障碍。