Cardenas Eduardo I, Che Karlhans Fru, Konradsen Jon R, Bao Aihua, Lindén Anders
Division of Lung and Airway Research, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden.
Division of Clinical Immunology and Allergy, Department of Medicine Solna, Karolinska Institute, Stockholm, Sweden.
Expert Rev Respir Med. 2022 Mar;16(3):293-301. doi: 10.1080/17476348.2022.2045197. Epub 2022 Mar 2.
New targets are needed to enable more accurate diagnosis, monitoring and effective therapy in uncontrolled asthma and chronic obstructive pulmonary disease (COPD), two disorders characterized by pathogenic alterations in the innate immune response. Interestingly, the IL-10-related cytokine IL-26 has been found to be abundantly expressed in human airways and alterations in its expression have been linked to reduced lung function and markers of neutrophilic inflammation in patients with uncontrolled asthma or COPD.
Literature search was conducted on PubMed to identify articles in the field of IL-26 immunology, as well as clinical studies on IL-26 in asthma and COPD, published between 2000 and 2021. We outline the main sources of IL-26 in human airways, as well as the effect of this cytokine on relevant immune and structural cells. Finally, we discuss the potential involvement of IL-26 in the pathophysiology of uncontrolled asthma and COPD.
IL-26 constitutes a potential target for diagnostic purposes and therapeutic modulation of the innate immune response in the airways of patients with asthma and COPD. It seems reasonable to expect more conclusive evidence of its clinical utility for personalized medicine within the coming 5-year period.
在未控制的哮喘和慢性阻塞性肺疾病（COPD）中，需要新的靶点来实现更准确的诊断、监测和有效治疗，这两种疾病的特征是固有免疫反应发生致病性改变。有趣的是，已发现白细胞介素10相关细胞因子白细胞介素26（IL-26）在人类气道中大量表达，其表达改变与未控制的哮喘或COPD患者的肺功能降低及中性粒细胞炎症标志物有关。
在PubMed上进行文献检索，以识别2000年至2021年间发表的关于IL-26免疫学领域的文章以及关于哮喘和COPD中IL-26的临床研究。我们概述了人类气道中IL-26的主要来源，以及这种细胞因子对相关免疫和结构细胞的影响。最后，我们讨论了IL-26在未控制的哮喘和COPD病理生理学中的潜在作用。
IL-26构成了哮喘和COPD患者气道固有免疫反应诊断和治疗调节的潜在靶点。预计在未来5年内会有更多关于其在个性化医疗中临床效用的确凿证据，这似乎是合理的。
