Chemical Food Safety Group, Nestlé Research, Lausanne, Switzerland.
Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy.
Methods Mol Biol. 2022;2425:479-495. doi: 10.1007/978-1-0716-1960-5_18.
Industrial needs and regulatory requirements have played a significant role in accelerating the use of nontesting methods including in silico tools as alternatives to animal testing. The main interest is not solely on the use of in silico tools, or in read-across, but on better toxicological safety assessment of substances, and for this purpose more advanced, integrated strategies have to be implemented. VEGAHUB wants to promote this broader view, not necessarily focused on a specific approach. Applying multiple tools and complementary approaches instead of one technique may provide more elements for a more robust evaluation, but at the same time it is important to have a conceptual scheme to integrate multiple, heterogeneous lines of evidence. We will show how the user can benefit from the diversity of tools available within the platform VEGAHUB for assessing the biological properties of chemical substances on an example of (non)mutagenicity.
工业需求和监管要求在加速使用非测试方法方面发挥了重要作用，包括计算工具作为动物测试的替代品。主要关注点不仅仅是使用计算工具或读码，而是更好地进行物质的毒理学安全性评估，为此目的，必须实施更先进、综合的策略。VEGAHUB 希望促进这种更广泛的观点，不一定专注于特定方法。应用多种工具和互补方法而不是一种技术，可能会为更稳健的评估提供更多元素，但同时，重要的是要有一个概念框架来整合多种异类证据线索。我们将展示用户如何从 VEGAHUB 平台中可用的各种工具中受益，以（非）致突变性为例评估化学物质的生物学特性。
