Department of Dermatology, Third People's Hospital of Hangzhou, Hangzhou, China.
Skin Res Technol. 2022 May;28(3):433-438. doi: 10.1111/srt.13143. Epub 2022 Feb 21.
Primary cutaneous amyloidosis (PCA) is apruritic and potentially disfiguring disorder; this disease is usually diagnosed clinically due to its common occurrence. However, for cases with atypical presentations or for those physicians not familiar with PCA, the diagnosis can be a challenge.
To observe the characteristics of PCA under dermoscopy and reflectance confocal microscopy (RCM) in order to gain experience and reference for clinicians to facilitate diagnosis.
The typical lesions of 110 patients with primary cutaneous amyloidosis were observed by dermoscopy and RCM, and scanning results were recorded. Thirty patients followed by complete excision for histopathological analysis.
A total of 110 patients with clinically diagnosed PCA were enrolled. Forty-seven patients had lesions consistent with macular amyloidosis and 63 with lichen amyloidosus. The dermoscopic findings of PCA shared a common feature, each 'macule' was composed of a central hub pattern surrounded by brownish pigmentation, The pattern of the central hub could be brown, white, scar-like and structureless area. RCM features of total patients consisted of dermal papilla present cloud-like agglomerate which are high refractive index.
Dermoscopy and reflectance confocal microscopy can be used in the diagnosis of PCA, which can provide a basis for doctors to diagnose.
原发性皮肤淀粉样变性（PCA）是一种瘙痒且可能影响容貌的疾病；由于其常见发生，通常通过临床诊断。但是，对于表现不典型的病例或不熟悉 PCA 的医生，诊断可能具有挑战性。
观察皮肤镜和反射共聚焦显微镜（RCM）下 PCA 的特征，为临床医生提供经验和参考，以促进诊断。
对 110 例原发性皮肤淀粉样变性的典型皮损进行皮肤镜和 RCM 观察，并记录扫描结果。对 30 例患者进行完全切除进行组织病理学分析。
共纳入 110 例临床诊断为 PCA 的患者。47 例患者皮损符合斑状淀粉样变性，63 例患者皮损符合苔藓样淀粉样变性。PCA 的皮肤镜表现具有共同特征，每个“斑”由中央结节模式环绕棕色色素沉着组成。中央结节的模式可以是棕色、白色、瘢痕样和无结构区域。所有患者的 RCM 特征均为呈云状聚集的真皮乳头，具有高折射率。
皮肤镜和反射共聚焦显微镜可用于 PCA 的诊断，为医生诊断提供依据。
