Department of Thoracic and Cardiovascular Surgery, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique des Hôpitaux de Paris, Sorbonne Université, Paris, France.
Department of Pharmacology and Clinical Investigation Center, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique des Hôpitaux de Paris, Sorbonne Université, Paris, France.
Clin Transplant. 2022 May;36(5):e14616. doi: 10.1111/ctr.14616. Epub 2022 Feb 22.
To evaluate the association between donors' and recipients' serum levels of soluble ST2 (sST2) and recipients' outcome after heart transplantation (HT).
Blood samples were collected in 50 heart donors before organ procurement and in 50 recipients before HT (D0), a week after HT (D7) and at every first year's endomyocardial biopsy (EMB); sST2 levels were evaluated by ELISA.
Donors who sustained a cardiac arrest, had significantly higher sST2 levels. Recipients on national high emergency waiting list had significantly higher preoperative sST2 levels compared to recipients who did not. Recipients with postoperative sepsis or continuous renal replacement therapy had significantly higher sST2 levels at D7. Recipients who needed a postoperative ECMO for allograft dysfunction had significantly higher sST2 levels in their corresponding donors. Recipients who died during the hospitalization after the transplantation had significantly higher sST2 levels at D7 compared to recipients who did not. No difference was observed in sST2 levels in recipients who had mild allograft rejection and recipient who did not.
Higher sST2 levels in donors are associated to allograft dysfunction requiring ECMO in recipients; higher postoperative sST2 levels in recipients are associated with in-hospital mortality.
评估供体和受体血清可溶性 ST2（sST2）水平与心脏移植（HT）后受体结局之间的关系。
在器官获取前采集 50 名心脏供体和 HT 前 50 名受体（D0）、HT 后一周（D7）和每年第一次心肌活检（EMB）时的血液样本；通过 ELISA 评估 sST2 水平。
发生心脏骤停的供体 sST2 水平显著升高。与未列入国家高紧急候补名单的受体相比，术前列入国家高紧急候补名单的受体 sST2 水平显著升高。术后发生脓毒症或持续肾脏替代治疗的受体 D7 时 sST2 水平显著升高。因供体功能障碍需要术后 ECMO 的受体，其相应供体的 sST2 水平显著升高。与未死亡的受体相比，移植后住院期间死亡的受体 D7 时 sST2 水平显著升高。发生轻度移植物排斥反应的受体和未发生移植物排斥反应的受体的 sST2 水平无差异。
供体中较高的 sST2 水平与需要 ECMO 的受体的移植物功能障碍有关；受体术后较高的 sST2 水平与住院期间的死亡率有关。
