Renton K W
Clin Biochem. 1986 Apr;19(2):72-5. doi: 10.1016/s0009-9120(86)80051-0.
Biotransformation of drugs to polar metabolites is a key step in the termination of action and the elimination of drugs used in therapeutics. A large number of factors, including infection, alter the basal rates of drug metabolism and cause a number of untoward effects and drug interactions. Although a number of techniques have been attempted, there appears to be no easy way to determine the capacity of an individual to metabolize a specific drug and to tailor drug dosage to that individual.
药物转化为极性代谢产物是治疗用药物作用终止和消除过程中的关键步骤。包括感染在内的大量因素会改变药物代谢的基础速率，并导致许多不良影响和药物相互作用。尽管已经尝试了多种技术，但似乎没有简单的方法来确定个体代谢特定药物的能力并据此为该个体量身定制药物剂量。
