建模脉搏波速度轨迹——挑战、机遇和陷阱。
Modeling pulse wave velocity trajectories-challenges, opportunities, and pitfalls.
机构信息
Section for Clinical Biometrics, Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, Vienna, Austria.
Section for Clinical Biometrics, Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, Vienna, Austria.
出版信息
Kidney Int. 2022 Mar;101(3):459-462. doi: 10.1016/j.kint.2021.12.025.
In this commentary, we discuss the analysis of trajectories of pulse wave velocity in a longitudinal cohort study of children with chronic kidney disease (the Cardiovascular Comorbidity in Children with Chronic Kidney Disease - Transplantation study). We revisit the analysis made by the study authors and unravel some additional limitations. We also reevaluate the implicit assumptions that were made in the chosen analysis and suggest extensions of the basic linear mixed model to obtain more differentiated answers to research questions in nephrology.
在这篇评论中，我们讨论了对患有慢性肾脏病的儿童进行纵向队列研究（心血管合并症在患有慢性肾脏病的儿童中的研究-移植研究）中脉搏波速度轨迹的分析。我们重新审视了研究作者的分析，并揭示了一些其他的局限性。我们还重新评估了在所选分析中做出的隐含假设，并提出了基本线性混合模型的扩展，以更深入地回答肾脏病学中的研究问题。
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