Filippova G O, Karpov L M, Rozanov A Ia
Ukr Biokhim Zh (1978). 1978 Mar-Apr;50(2):192-6.
Lipoic acid intake following parenteral administration with functionally linked vitamins depends on molar relations between them. It is shown that a combined administration of 35S-lipoate with these vitamins decreases radioactivity 30-120 min after the injection in most of tissues as compared to the control, except for the liver where it does not change or increases (60 min after administration in combination with thiamin or pantothenate). Following 18h thiamin and mixture of vitamins induce an intensified intake of labelled lipoic acid by the brain tissue, a 4-fold increase in case of thiamin and a 2.6-fold increase in case of the vitamins mixture.
肠胃外给予与功能相关的维生素后，硫辛酸的摄取量取决于它们之间的摩尔关系。结果表明，与对照组相比，在注射后30 - 120分钟，35S - 硫辛酸与这些维生素联合给药会使大多数组织中的放射性降低，但肝脏除外，在肝脏中放射性不变或增加（与硫胺素或泛酸盐联合给药60分钟后）。给予硫胺素18小时后以及给予维生素混合物后，脑组织对标记硫辛酸的摄取增强，硫胺素给药后增加4倍，维生素混合物给药后增加2.6倍。
