Surber Christian, Plautz James, Osterwalder Uli
Dermatologische Klinik, UniversitätsSpital Zürich, Gloriastr. 31, 8091, Zürich, Schweiz.
Dermatologische Klinik, Universitätsspital Basel, Petersgraben 4, 4031, Basel, Schweiz.
Hautarzt. 2022 Apr;73(4):266-274. doi: 10.1007/s00105-022-04954-1. Epub 2022 Feb 21.
Sunscreen products containing inorganic micronized titanium dioxide (TiO) and zinc oxide (ZnO) have been available since the 1950s. Their cosmetic acceptance remained limited as they persist as a white paste on the skin. By reducing the size of the particles into the nano-range below 100 nm, their optical property of reflecting visible light is reduced. After the year 2000, organic filters of this size range were developed. The enthusiasm for nanotechnology that prevailed at the time did not transfer to sunscreen products with nanoparticulate filters. Consumers suspect that the particles permeate the skin, are absorbed by the blood, and spread throughout the body causing illness. Not least due to public pressure, cosmetics-which include sunscreen products-became the first product segment in which accordingly manufactured substances were subjected to strict regulations. Despite advanced regulation and strict approval procedures for nanoparticulate filters, public reservations remained. Possible reasons for this are lack of knowledge or mistrust of the applicable legislation, unclear perception of the behavior of nanoparticles in sunscreen products and as a result unclear perceptions of hazard, risk, and exposure. Against this background, the nature and behavior of nanoparticulate filters in sunscreens on the skin and potentially in the skin, as well as the regulatory framework that ensure that nanoparticulate filters and the products containing them are safe to use are discussed.
自20世纪50年代以来,含有无机微粉化二氧化钛(TiO)和氧化锌(ZnO)的防晒产品就已问世。由于它们会在皮肤上残留为白色糊状物,其在化妆品领域的接受度一直有限。通过将颗粒尺寸减小到100纳米以下的纳米范围,它们反射可见光的光学特性会降低。2000年以后,开发出了这种尺寸范围的有机滤光剂。当时盛行的对纳米技术的热情并未转移到含有纳米颗粒滤光剂的防晒产品上。消费者怀疑这些颗粒会渗透皮肤、被血液吸收并扩散到全身从而致病。尤其是在公众压力下,包括防晒产品在内的化妆品成为首个对相应制造物质实施严格监管的产品领域。尽管对纳米颗粒滤光剂有先进的监管和严格的审批程序,但公众的疑虑依然存在。造成这种情况的可能原因包括对适用法规缺乏了解或不信任、对纳米颗粒在防晒产品中的行为认知不清,以及因此对危害、风险和暴露的认知不清。在此背景下,本文讨论了纳米颗粒滤光剂在皮肤上以及可能在皮肤内的防晒产品中的性质和行为,以及确保纳米颗粒滤光剂及其所含产品安全使用的监管框架。