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Letter to the editor regarding "Dietary bovine milk miRNAs transported in extracellular vesicles are partially stable during GI digestion, are bioavailable and reach target tissues but need a minimum dose to impact on gene expression".

作者信息

Melnik Bodo C, Weiskirchen Ralf, Stremmel Wolfgang, Schmitz Gerd

机构信息

Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabrück, 49076, Osnabrück, Germany.

Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH University Hospital Aachen, 52074, Aachen, Germany.

出版信息

Eur J Nutr. 2022 Apr;61(3):1695-1696. doi: 10.1007/s00394-022-02817-y. Epub 2022 Feb 22.

DOI:10.1007/s00394-022-02817-y
PMID:35192027
Abstract
摘要

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本文引用的文献

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Association of Circulating Biomarkers of lnc-IGSF3-1:1, SCOC-AS1, and SLC8A1-AS1 with Salt Sensitivity of Blood Pressure in Chinese Population.lnc-IGSF3-1:1、SCOC-AS1 和 SLC8A1-AS1 循环生物标志物与中国人群血压盐敏感性的关系。
J Cardiovasc Transl Res. 2022 Aug;15(4):906-917. doi: 10.1007/s12265-021-10190-0. Epub 2021 Dec 2.
2
Exosome-Derived MicroRNAs of Human Milk and Their Effects on Infant Health and Development.人乳来源的外泌体 microRNAs 及其对婴儿健康和发育的影响。
Biomolecules. 2021 Jun 7;11(6):851. doi: 10.3390/biom11060851.
3
Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis.
口服牛源细胞外囊泡诱导原发性肿瘤衰老，但加速癌症转移。
Nat Commun. 2021 Jun 24;12(1):3950. doi: 10.1038/s41467-021-24273-8.
4
Milk Exosomes Prevent Intestinal Inflammation in a Genetic Mouse Model of Ulcerative Colitis: A Pilot Experiment.牛奶外泌体在溃疡性结肠炎基因小鼠模型中预防肠道炎症：一项初步实验
Inflamm Intest Dis. 2020 Aug;5(3):117-123. doi: 10.1159/000507626. Epub 2020 May 20.
5
Milk-derived exosomes (MDEs) have a different biological effect on normal fetal colon epithelial cells compared to colon tumor cells in a miRNA-dependent manner.乳源外泌体（MDE）通过 miRNA 依赖的方式对正常胎儿结肠上皮细胞产生不同于结肠肿瘤细胞的生物学效应。
J Transl Med. 2019 Sep 30;17(1):325. doi: 10.1186/s12967-019-2072-3.
6
Exosomes of pasteurized milk: potential pathogens of Western diseases.巴氏消毒奶中的外泌体：西方疾病的潜在病原体。
J Transl Med. 2019 Jan 3;17(1):3. doi: 10.1186/s12967-018-1760-8.
7
Concentrations of Purine Metabolites Are Elevated in Fluids from Adults and Infants and in Livers from Mice Fed Diets Depleted of Bovine Milk Exosomes and their RNA Cargos.从成人和婴儿的体液以及用缺乏牛源乳外泌体及其 RNA cargos 的饮食喂养的小鼠的肝脏中，可检测到嘌呤代谢物浓度升高。
J Nutr. 2018 Dec 1;148(12):1886-1894. doi: 10.1093/jn/nxy223.
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The Potential of Exosomes From Cow Milk for Oral Delivery.牛乳来源外泌体的口服递送潜力。
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Sci Rep. 2018 Jul 27;8(1):11321. doi: 10.1038/s41598-018-29780-1.