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lnc-IGSF3-1:1、SCOC-AS1 和 SLC8A1-AS1 循环生物标志物与中国人群血压盐敏感性的关系。

Association of Circulating Biomarkers of lnc-IGSF3-1:1, SCOC-AS1, and SLC8A1-AS1 with Salt Sensitivity of Blood Pressure in Chinese Population.

机构信息

Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, No. 10, Xi Toutiao You Anmenwai, Fengtai District, Beijing, 100069, China.

Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, 100069, China.

出版信息

J Cardiovasc Transl Res. 2022 Aug;15(4):906-917. doi: 10.1007/s12265-021-10190-0. Epub 2021 Dec 2.

DOI:10.1007/s12265-021-10190-0
PMID:34855149
Abstract

Accumulating evidence suggested that long non-coding RNAs (lncRNAs) could play biological roles in cardiovascular diseases. We investigated whether lncRNAs can serve as biomarkers for salt sensitivity of blood pressure (SSBP). Participants were divided into salt-sensitive (SS) and salt-resistant (SR) ones by oral saline test. LncRNAs were tested by microarray (N = 20) and two-stage qRT-PCR (N = 89 and 228). We identified five differently expressed lncRNAs (lnc-IGSF3-1:1, SCOC-AS1, SLC8A1-AS1, KCNQ1OT1, and lnc-GNG-10-3:1) between SS and SR. In single-lncRNA analyses, lnc-IGSF3-1:1 displayed better diagnostic performance in hypertensive patients (AUC = 0.840), while SCOC-AS1 in normotensive (AUC = 0.810). In multi-lncRNA analyses, lnc-IGSF3-1:1 + SCOC-AS1 + SLC8A1-AS1 combination showed the best diagnostic performance in hypertensive (AUC = 0.853) and normotensive groups (AUC = 0.873). We constructed a lncRNA-mRNA-GO-KEGG-disease network by bioinformatic analysis; lnc-IGSF3-1:1 and SLC8A1-AS1 were identified as hub biomarkers. Our findings suggest that lnc-IGSF3-1:1, SCOC-AS1, and SLC8A1-AS1 may represent as genetic susceptible biomarkers for SSBP, and had different SS diagnostic performance in hypertensive patients and normotensive individuals.

摘要

越来越多的证据表明，长链非编码 RNA（lncRNA）在心血管疾病中可能发挥生物学作用。我们研究了 lncRNA 是否可以作为血压盐敏感性（SSBP）的生物标志物。通过口服盐水试验将参与者分为盐敏感（SS）和盐抵抗（SR）。通过微阵列（N=20）和两阶段 qRT-PCR（N=89 和 228）测试 lncRNA。我们在 SS 和 SR 之间鉴定了五个不同表达的 lncRNA（lnc-IGSF3-1:1、SCOC-AS1、SLC8A1-AS1、KCNQ1OT1 和 lnc-GNG-10-3:1）。在单 lncRNA 分析中，lnc-IGSF3-1:1 在高血压患者中显示出更好的诊断性能（AUC=0.840），而 SCOC-AS1 在正常血压者中（AUC=0.810）。在多 lncRNA 分析中，lnc-IGSF3-1:1+SCOC-AS1+SLC8A1-AS1 组合在高血压（AUC=0.853）和正常血压组（AUC=0.873）中表现出最佳的诊断性能。通过生物信息学分析构建了 lncRNA-mRNA-GO-KEGG-疾病网络；lnc-IGSF3-1:1 和 SLC8A1-AS1 被鉴定为枢纽生物标志物。我们的研究结果表明，lnc-IGSF3-1:1、SCOC-AS1 和 SLC8A1-AS1 可能代表 SSBP 的遗传易感生物标志物，并且在高血压患者和正常血压个体中具有不同的 SS 诊断性能。

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