Lunacek Andreas, Tischler Mathias, Mrstik Christof, Hebenstreit Doris, Oeser Reinhard, Bektic Jasmin, Klocker Helmut, Horninger Wolfgang, Plas Eugen
Department of Urology, Hanusch Krankenhaus, Vienna, Austria.
Department of Urology, Medical University of Innsbruck, Innsbruck, Austria.
Prostate. 2022 May;82(7):804-808. doi: 10.1002/pros.24322. Epub 2022 Feb 22.
To determine the effects if cycling and rowing on serum prostate-specific antigen (PSA) levels.
Male volunteers (n = 101), aged 20-80 (mean, 49.9) years were randomized to exercise at the first or second study visit. They performed 1 h of either cycling or rowing on a stationary machine. To determine exercise-induced effects on the PSA level, serum total PSA (tPSA) and free PSA (fPSA) concentrations were evaluated before and after exercise and another sampling was performed at the second study visit. Pre-exercise and postexercise tPSA and fPSA concentrations were compared using the Wilcoxon matched-pairs test. The results were analyzed using the Mann-Whitney U-test.
A significant (p < 0.001) average increase in tPSA after exercise (1.14 ± 1.11 ng/ml to 1.24 ± 1.26 ng/ml [mean, +8.8%]) was observed after both cycling and rowing, without significant differences between the sports (p = 0.54). The exercise-induced increase in PSA concentration affected participants aged ≥50 years (difference, 0.16 ± 0.37; p < 0.001), but not those aged <50 years (difference, 0.01 ± 0.06; p = 0.23). The effect size was clinically irrelevant in all except two outliers, in whom a distinct increase of PSA level by averages of 1.80 ng/ml (+55%) for tPSA and 1.25 ng/ml (+227%) for fPSA following cycling was observed.
Rowing and cycling generally do not have a clinically relevant effect on PSA levels. However, outliers exist. Our findings do not support abstaining from exercise during the days approaching PSA sampling.
确定骑自行车和划船运动对血清前列腺特异性抗原（PSA）水平的影响。
年龄在20 - 80岁（平均49.9岁）的男性志愿者（n = 101）被随机分配在第一次或第二次研究访视时进行运动。他们在固定器械上进行1小时的骑自行车或划船运动。为了确定运动对PSA水平的影响，在运动前后评估血清总PSA（tPSA）和游离PSA（fPSA）浓度，并在第二次研究访视时进行另一次采样。使用Wilcoxon配对检验比较运动前和运动后tPSA和fPSA的浓度。结果采用Mann-Whitney U检验进行分析。
骑自行车和划船运动后均观察到tPSA平均显著升高（p < 0.001）（从1.14 ± 1.11 ng/ml升至1.24 ± 1.26 ng/ml [平均，升高8.8%]），两种运动之间无显著差异（p = 0.54）。运动引起的PSA浓度升高影响了年龄≥50岁的参与者（差异为0.16 ± 0.37；p < 0.001），但对年龄<50岁的参与者无影响（差异为0.01 ± 0.06；p = 0.23）。除了两个异常值外，效应量在临床上均无意义，在这两个异常值中，观察到骑自行车后tPSA平均显著升高1.80 ng/ml（+55%），fPSA平均显著升高1.25 ng/ml（+227%）。
划船和骑自行车运动通常对PSA水平无临床相关影响。然而，存在异常值。我们的研究结果不支持在接近PSA采样的日子里避免运动。
