Prescott J F
Vet Pathol. 1978 Mar;15(2):237-48. doi: 10.1177/030098587801500210.
An outbreak of severe diarrhoea and death in young rabbits was associated with many nonenterotoxigenic Escherichia coli in the caecum. The severe clinical, pathological and bacteriological features of the diesase, acute diarrhoea associated with typhlitis and many E. coli in the caecum, could be reproduced either by the intraintestinal inoculation of many bacteria recovered aerobically or anaerobically from the caecum of these rabbits or by the intestinal inoculation of large numbers of a serogroup of E. coli, 0153, recovered from the caecum. Further experiments showed that this serogroup of E. coli, as well as a nonenteropathogenic serotype recovered from human faeces, would cause typhlitis and diarrhoea if inoculated in large numbers into the jejunum; pathological changes also were seen in the liver and kidney. Similar changes also could be induced by intravenous inoculation of a freeze-thaw (endotoxic) extract prepared from these strains. Any factor that allows rapid multiplication of E. coli in the rabbit caecum may be followed by absorption of endotoxin and subsequent typhlitis and so metimes by severe diarrhoea; this effect is seen in some field cases of diarrhoea in the rabbit.
幼兔中出现的严重腹泻和死亡疫情与盲肠中许多非产肠毒素大肠杆菌有关。该病严重的临床、病理和细菌学特征，即伴有盲肠炎的急性腹泻以及盲肠中存在许多大肠杆菌，可通过对从这些兔子盲肠中需氧或厌氧回收的许多细菌进行肠道内接种，或通过对从盲肠中回收的大量大肠杆菌血清群0153进行肠道接种来重现。进一步的实验表明，这种大肠杆菌血清群以及从人类粪便中回收的一种非致病性血清型，如果大量接种到空肠中，会导致盲肠炎和腹泻；肝脏和肾脏也出现了病理变化。通过静脉接种由这些菌株制备的冻融（内毒素）提取物也可诱导出类似变化。任何使大肠杆菌在兔盲肠中快速繁殖的因素，随后可能会导致内毒素吸收以及随后的盲肠炎，有时还会导致严重腹泻；这种效应在兔腹泻的一些现场病例中可见。
