Guo Wenping, Qu Yongtao, Guo Mingli, Xu Xia
Department of Otolaryngology Head and Neck Surgery，Shijiazhuang People's Hospital，Shijiazhuang，050057，China.
Department of Otolaryngology Head and Neck Surgery，Hebei General Hospital.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2022 Mar;36(3):172-176. doi: 10.13201/j.issn.2096-7993.2022.03.003.
To analyze the coagulation status and prognosis of sudden deafness patients with total deafness accompanied by vertigo, and to provide basis for improving the treatment of this disease. From January 2017 to December 2020, 33 patients with total deafness and vertigo sudden deafness who were hospitalized in the Department of Otolaryngology Head and Neck Surgery, Hebei Provincial People's Hospital were selected as the research group. During the same period, 33 cases of low frequency type, full frequency type, total deafness and 26 cases of high frequency type were treated as control group.Thirty-three cases of inpatients without history of middle ear and inner ear diseases were treated as normal control group. The levels of fibrinogen（FIB）, D-Dimer（D-D）, Prothrombin Time（PT）, Activated Partial Thrombin Time（APTT） between the research group and the control group were analyzed, and the therapeutic effects of different types of sudden deafness patients were analyzed. FIB and D-D of total deafness with vertigo were 2.50（2.11, 2.95）and 0.27（0.16, 0.51） respectively, which were higher than 2.31（1.92, 2.50） and 0.17（0.12, 0.21） of normal group. APTT was 25.2（23.1, 28.1）, lower than 27.3（26.4, 29.7） in the normal group, the differences were statistically significant（<0.01）. ② FIB of total deafness with vertigo was 2.50（2.11, 2.95）, which was higher than that of low frequency group 2.37（1.81, 2.68）. D-D was 0.27（0.16, 0.51）, higher than low frequency group 0.16（0.12, 0.25）, high frequency group of 0.13（0.11, 0.23）, the whole frequency group 0.16（0.11, 0.28）, total of 0.18（1.45, 0.30）. APTT was 25.75±3.18/25.2（23.1, 28.1）, lower than 27.72±2.22 in low frequency group and 26.7（25.8, 28.7） in full frequency group, with statistical significance（<0.05）. ③ The total deafness with vertigo group had the worst curative effect（ineffective rate was 63.6%）, and the low frequency group had the best curative effect（recovery rate was 75.8%）. The difference of curative effect among different types of sudden deafness groups was statistically significant（<0.05）. Hypercoagulability and thrombosis may be one of the influencing factors of total sudden deafness. The hypercoagulable state of sudden deafness patients with total deafness and vertigo is more serious than that of total deafness and other types of sudden deafness, and the prognosis is the worst.
分析全聋伴眩晕突发性聋患者的凝血状态及预后，为改善该病的治疗提供依据。选取2017年1月至2020年12月在河北省人民医院耳鼻咽喉头颈外科住院的33例全聋伴眩晕突发性聋患者作为研究组。同期选取33例低频型、全频型、全聋型及26例高频型患者作为对照组。选取33例无中耳及内耳疾病史的住院患者作为正常对照组。分析研究组与对照组之间纤维蛋白原（FIB）、D-二聚体（D-D）、凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）水平，并分析不同类型突发性聋患者的治疗效果。全聋伴眩晕患者的FIB和D-D分别为2.50（2.11，2.95）和0.27（0.16，0.51），高于正常组的2.31（1.92，2.50）和0.17（0.12，0.21）。APTT为25.2（23.1，28.1），低于正常组的27.3（26.4，29.7），差异有统计学意义（<0.01）。②全聋伴眩晕患者的FIB为2.50（2.11，2.95），高于低频组的2.37（1.81，2.68）。D-D为0.27（0.16，0.51），高于低频组的0.16（0.12，0.25）、高频组的0.13（0.11，0.23）、全频组的0.16（0.11，0.28）、全聋组的0.18（1.45，0.30）。APTT为25.75±3.18/25.2（23.1，28.1），低于低频组的27.72±2.22和全频组的26.7（25.8，28.7），差异有统计学意义（<0.05）。③全聋伴眩晕组疗效最差（无效 率为63.6%），低频组疗效最佳（痊愈率为75.8%）。不同类型突发性聋组间疗效差异有统计学意义（<0.05）。高凝状态及血栓形成可能是全聋型突发性聋的影响因素之一。全聋伴眩晕突发性聋患者的高凝状态较全聋型及其他类型突发性聋更严重，预后最差。
