Yuan J, Xu S S, Zhang X L, Fan Y Y, Wang Y F
Department of Otorhinolaryngology Head and Neck Surgery, Binzhou Medical University Hospital, Binzhou, 256603, China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2019 May;33(5):421-424. doi: 10.13201/j.issn.1001-1781.2019.05.009.
To study the correlation between the prognosis of sudden deafness and laboratory indicators, and to provide a theoretical basis for clinical evaluation of prognosis and selection of appropriate interventions. A retrospective analysis of 123 cases of total deafness was conducted(all frequencies decreased with 250-8 000 Hz average hearing threshold ≥ 81 dB HL). All patients admitted to the hospital received laboratory test within 24 hours and underwent a unified treatment: alprostadil + mecobalamin + citicoline sodium phosphate + Ginkgo biloba extract + batroxobin + methylprednisolone (patients with hypertension or diabetes were given retro-auricular injection). After 2 weeks of comprehensive treatment, the pure tone audiometry was reviewed and the clinical efficacy was evaluated. According to the prognosis, the patients were divided into the healing group, the marked effective group, the effective group and the ineffective group. The laboratory indicators included: white blood cell count, neutrophil percentage, neutrophil lymphocyte ratio(NHR), erythrocyte sedimentation rate, blood lipid, red blood cell count, hemoglobin(Hb), plasma fibrinogen content(FIB). There were no significant differences in white blood cell count, neutrophil percentage, NHR, erythrocyte sedimentation rate, blood lipid index and red blood cell count between different prognosis groups(all >0.05). The differences of FIB and Hb were statistically significant(<0.05). The overall prognosis was negatively correlated with FIB and positively correlated with Hb. Patients with vertigo had a worse prognosis and a higher plasma FIB level than those without vertigo(<0.05), but there was no significant difference of Hb between patients with and without vertigo(>0.05). FIB and Hb can be used as correlative indexes to evaluate the prognosis of patients with sudden deafness, and the effects of vertigo and other associated symptoms on the prognosis should be comprehensively analyzed. .
研究突发性聋预后与实验室指标的相关性，为临床预后评估及选择合适干预措施提供理论依据。对123例全聋患者（所有频率250～8 000 Hz平均听阈≥81 dB HL）进行回顾性分析。所有入院患者均于24小时内进行实验室检查并接受统一治疗：前列地尔+甲钴胺+磷酸胞胆碱钠+银杏叶提取物+巴曲酶+甲泼尼龙（高血压或糖尿病患者给予耳后注射）。综合治疗2周后复查纯音听力测定并评估临床疗效。根据预后将患者分为痊愈组、显效组、有效组和无效组。实验室指标包括：白细胞计数、中性粒细胞百分比、中性粒细胞淋巴细胞比值（NHR）、血沉、血脂、红细胞计数、血红蛋白（Hb）、血浆纤维蛋白原含量（FIB）。不同预后组间白细胞计数、中性粒细胞百分比、NHR、血沉、血脂指标及红细胞计数比较差异均无统计学意义（均>0.05）。FIB与Hb差异有统计学意义（<0.05）。总体预后与FIB呈负相关，与Hb呈正相关。有眩晕的患者较无眩晕者预后差，血浆FIB水平更高（<0.05），但有眩晕与无眩晕患者Hb比较差异无统计学意义（>0.05）。FIB与Hb可作为评估突发性聋患者预后的相关指标，应综合分析眩晕等伴随症状对预后的影响。
