[干细胞内耳移植的进展]
[Advances in stem cell inner ear transplantation].
作者信息
Hua Rongkai, Hua Qingquan
出版信息
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2022 Mar;36(3):239-242. doi: 10.13201/j.issn.2096-7993.2022.03.017.
Abstract
Sensorineural hearing loss has long been one of the common diseases in the field of otology. With the increasing research on stem cell therapy, the experiments and applications of stem cell inner ear transplantation are developing rapidly, with some remarkable results and some questions to be considered. The source of stem cells and the transplantation route are crucial, and the immune rejection in the post-transplantation period should not be ignored. This paper will review the issues related to stem cell source, transplantation route and immune rejection in inner ear transplantation, hoping to provide new ideas for research in the field of stem cell inner ear transplantation.
摘要
感音神经性听力损失长期以来一直是耳科学领域的常见疾病之一。随着对干细胞治疗研究的不断增加，干细胞内耳移植的实验和应用发展迅速，取得了一些显著成果，但也存在一些问题需要考虑。干细胞的来源和移植途径至关重要，移植后时期的免疫排斥也不容忽视。本文将综述内耳移植中与干细胞来源、移植途径和免疫排斥相关的问题，希望为干细胞内耳移植领域的研究提供新思路。
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本文引用的文献
1
Immune reaction and regulation in transplantation based on pluripotent stem cell technology.基于多能干细胞技术的移植免疫反应与调控
Inflamm Regen. 2020 Jul 1;40:12. doi: 10.1186/s41232-020-00125-8. eCollection 2020.
2
Syngeneic Mesenchymal Stem Cells Reduce Immune Rejection After Induced Pluripotent Stem Cell-Derived Allogeneic Cardiomyocyte Transplantation.同种异体间充质干细胞减少诱导多能干细胞源性同种异体心肌细胞移植后的免疫排斥反应。
Sci Rep. 2020 Mar 12;10(1):4593. doi: 10.1038/s41598-020-58126-z.
3
The transplantation of induced pluripotent stem cells into the cochleae of mature mice.将诱导多能干细胞移植到成年小鼠的耳蜗中。
Int J Clin Exp Pathol. 2018 Sep 1;11(9):4423-4430. eCollection 2018.
4
Progenitor Cells from the Adult Human Inner Ear.成人内耳的祖细胞。
Anat Rec (Hoboken). 2020 Mar;303(3):461-470. doi: 10.1002/ar.24228. Epub 2019 Sep 5.
5
Advances in stem cell research and therapeutic development.干细胞研究与治疗开发的进展。
Nat Cell Biol. 2019 Jul;21(7):801-811. doi: 10.1038/s41556-019-0344-z. Epub 2019 Jun 17.
6
Taurine enhances mouse cochlear neural stem cell transplantation via the cochlear lateral wall for replacement of degenerated spiral ganglion neurons via sonic hedgehog signaling pathway.牛磺酸通过耳蜗侧墙增强小鼠耳蜗神经干细胞移植，通过 sonic hedgehog 信号通路替代退化的螺旋神经节神经元。
Cell Tissue Res. 2019 Oct;378(1):49-57. doi: 10.1007/s00441-019-03018-6. Epub 2019 Apr 17.
7
Engraftment of Human Stem Cell-Derived Otic Progenitors in the Damaged Cochlea.人源干细胞源性耳前体细胞在受损耳蜗中的植入。
Mol Ther. 2019 Jun 5;27(6):1101-1113. doi: 10.1016/j.ymthe.2019.03.018. Epub 2019 Apr 2.
8
Traditional oriental medicine for sensorineural hearing loss: Can ethnopharmacology contribute to potential drug discovery?传统东方医学治疗感音神经性听力损失：民族药理学能否有助于潜在药物的发现？
J Ethnopharmacol. 2019 Mar 1;231:409-428. doi: 10.1016/j.jep.2018.11.016. Epub 2018 Nov 12.
9
Combination of MSC spheroids wrapped within autologous composite sheet dually protects against immune rejection and enhances stem cell transplantation efficacy.包裹在自体复合片内的间充质干细胞球体组合可双重保护免受免疫排斥并提高干细胞移植效果。
Tissue Cell. 2018 Aug;53:93-103. doi: 10.1016/j.tice.2018.06.005. Epub 2018 Jun 28.
10
Induced Pluripotent Stem Cells Promote Retinal Ganglion Cell Survival After Transplant.诱导多能干细胞促进移植后视网膜神经节细胞存活。
Invest Ophthalmol Vis Sci. 2018 Mar 1;59(3):1571-1576. doi: 10.1167/iovs.17-23648.
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