干细胞研究与治疗开发的进展。

Advances in stem cell research and therapeutic development.

机构信息

Center for Regenerative Medicine "Stefano Ferrari", Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy.

San Raffaele Telethon Institute for Gene Therapy (SR-Tiget) and Pediatric Immunohematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.

出版信息

Nat Cell Biol. 2019 Jul;21(7):801-811. doi: 10.1038/s41556-019-0344-z. Epub 2019 Jun 17.

DOI:10.1038/s41556-019-0344-z

PMID:31209293

Abstract

Despite many reports of putative stem-cell-based treatments in genetic and degenerative disorders or severe injuries, the number of proven stem cell therapies has remained small. In this Review, we survey advances in stem cell research and describe the cell types that are currently being used in the clinic or are close to clinical trials. Finally, we analyse the scientific rationale, experimental approaches, caveats and results underpinning the clinical use of such stem cells.

摘要

尽管有许多关于基于干细胞的治疗方法在遗传和退行性疾病或严重损伤中的报道，但已证实的干细胞疗法数量仍然很少。在这篇综述中，我们调查了干细胞研究的进展，并描述了目前正在临床使用或接近临床试验的细胞类型。最后，我们分析了这些干细胞在临床应用中的科学原理、实验方法、注意事项和结果。