Bradlaw J A
Fundam Appl Toxicol. 1986 May;6(4):598-606. doi: 10.1016/0272-0590(86)90172-7.
Approaches to the evaluation of drug and other chemical toxicity with mammalian cell culture systems are designed to enhance the predictability of animal models. Identification of toxic agents by in vitro screening tests and studies of mechanisms through which chemicals induce critical lesions at the cellular and subcellular levels help to make those predictions sooner and perhaps single out those target sites and chemicals of most concern.
利用哺乳动物细胞培养系统评估药物和其他化学物质毒性的方法旨在提高动物模型的预测能力。通过体外筛选试验识别有毒物质，并研究化学物质在细胞和亚细胞水平上诱导关键损伤的机制，有助于更快地做出这些预测，并可能找出最受关注的那些靶位点和化学物质。
