Bailone Ricardo Lacava, Fukushima Hirla Costa Silva, de Aguiar Luis Kluwe, Borra Ricardo Carneiro
Department of Genetic and Evolution, Federal University of São Carlos, Washington Luiz Road, km 230, São Carlos City, São Paulo County, 13565-905, Brazil.
Department of Federal Inspection Service, Federal Inspection Service, Ministry of Agriculture, Livestock and Supply of Brazil, Brasília, Brazil.
Lab Anim Res. 2022 Feb 22;38(1):5. doi: 10.1186/s42826-022-00116-5.
Zebrafish is considered an unprecedented animal model in drug discovery. A review of the literature presents highlights and elucidates the biological effects of chemical components found in Cannabis sativa. Particular attention is paid to endocannabinoid system (eCB) and its main receptors (CB1 and CB2). The zebrafish model is a promising one for the study of cannabinoids because of the many similarities to the human system. Despite the recent advances on the eCB system, there is still the need to elucidate some of the interactions and, thus, the zebrafish model can be used for that purpose as it respects the 3Rs concept and reduced time and costs. In view of the relevance of cannabinoids in the treatment and prevention of diseases, as well as the importance of the zebrafish animal model in elucidating the biological effects of new drugs, the aim of this study was to bring to light information on the use of the zebrafish animal model in testing C. sativa-based medicines.
斑马鱼被认为是药物研发中一种前所未有的动物模型。一篇文献综述展示了亮点，并阐明了大麻中发现的化学成分的生物学效应。特别关注内源性大麻素系统（eCB）及其主要受体（CB1和CB2）。由于斑马鱼模型与人类系统有许多相似之处，它是研究大麻素的一个有前景的模型。尽管最近在eCB系统方面取得了进展，但仍有必要阐明一些相互作用，因此斑马鱼模型可用于此目的，因为它符合3R原则，且能减少时间和成本。鉴于大麻素在疾病治疗和预防中的相关性，以及斑马鱼动物模型在阐明新药生物学效应方面的重要性，本研究的目的是揭示斑马鱼动物模型在测试基于大麻的药物方面的应用信息。
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