评估利培酮对斑马鱼胚胎的毒性。
Assessment of Risperidone Toxicity in Zebrafish () Embryos.
机构信息
Center of Biological and Health Sciences, Federal University of São Carlos, São Carlos, Brazil; Corresponding Author. hirlafukushima@gmail. com.
Department of Genetics and Evolution, Federal University of São Carlos, São Carlos, Brazil; Department of Federal Inspection Service, Ministry of Agriculture, Livestock and Supply of Brazil, São Carlos, Brazil.
出版信息
Comp Med. 2023 Aug 27;73(4):260-266. doi: 10.30802/AALAS-CM-22-000123. Epub 2023 Aug 3.
Abstract
Risperidone is an antipsychotic medication used in the treatment of conditions like autism and schizophrenia. The goal of the current study was to examine the effects of risperidone in zebrafish embryos ( ) with regard to survival, development, and cardiac and neural systems. The results showed that concentrations above 100 μM were associated with deaths, teratogenic effects, and cardiotoxic and neurotoxic effects. The findings support the utility of zebrafish for toxicological screening studies.
摘要
利培酮是一种抗精神病药物，用于治疗自闭症和精神分裂症等疾病。本研究旨在探讨利培酮对斑马鱼胚胎（ ）的生存、发育以及心脏和神经系统的影响。结果表明，浓度高于 100 μM 与死亡、致畸作用以及心脏毒性和神经毒性有关。这些发现支持斑马鱼用于毒理学筛选研究。
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