Kreuzfelder E, Rodeck U, Brittinger G, Kirch W, Scheiermann N
Immun Infekt. 1986 Apr;14(2):73-5.
In a longitudinal study of a female patient with systemic lupus erythematosus, we determined numbers of T-lymphocytes and subpopulations (OKT4+- and OKT8+-lymphocytes), B-lymphocytes, production of anti-double-stranded DNA antibody (anti-ds-DNA-Ab), and we investigated the effects of corticosteroids and cyclophosphamide on these parameters and clinical disease activity. The results demonstrate that an increase of OKT4+-T-lymphocytes/OKT8+-T-lymphocytes ratio apparently augments B-lymphocyte numbers resulting in anti-ds-DNA-Ab production. Whereas steroids exerted limited, possibly dose-dependent effects on this sequence, cyclophosphamide seemed to cause normalization of OKT4+/OKT8+ ratio, precipitous drop of anti-ds-DNA-Ab titers, and dramatic clinical improvement.
在一项针对一名系统性红斑狼疮女性患者的纵向研究中，我们测定了T淋巴细胞及其亚群（OKT4 + 淋巴细胞和OKT8 + 淋巴细胞）、B淋巴细胞的数量、抗双链DNA抗体（抗ds-DNA-Ab）的产生，并研究了皮质类固醇和环磷酰胺对这些参数以及临床疾病活动度的影响。结果表明，OKT4 + -T淋巴细胞/OKT8 + -T淋巴细胞比值的增加明显会使B淋巴细胞数量增多，从而导致抗ds-DNA-Ab的产生。虽然类固醇对这一过程的影响有限，可能存在剂量依赖性，但环磷酰胺似乎能使OKT4 + /OKT8 + 比值恢复正常，使抗ds-DNA-Ab滴度急剧下降，并使临床症状显著改善。
