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采用中心复合设计法开发并优化含美法仑的脂质-聚合物杂化纳米粒及其对卵巢癌细胞系的影响

Development and Optimization of Lipid-polymer Hybrid Nanoparticles Containing Melphalan Using Central Composite Design and Its Effect on Ovarian Cancer Cell Lines.

作者信息

Mirnezami Seyedeh Masoomeh Sadat, Heydarinasab Amir, Akbarzadehkhyavi Azim, Adrjmand Mehdi

机构信息

Department of Chemical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran .

Department of Pilot Nano-biotechnology, Pasteur Institute of Iran, Tehran, Iran.

出版信息

Iran J Pharm Res. 2021 Fall;20(4):213-228. doi: 10.22037/ijpr.2021.114575.14923.

DOI:10.22037/ijpr.2021.114575.14923
PMID:35194441
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8842616/
Abstract

The development of controlled-release drug delivery systems has a great potential to improve the efficacy of anticancer drugs. This study aimed to develop and optimize the production of hybrid lipid-polymer nanoparticles () for the targeted delivery of anticancer drugs. Response surface methodology () and central composite design () were used to evaluate and optimize the effects of three independent variables including lipid, polymer, and polyvinyl alcohol () ratios on the nanoparticles () size and drug entrapment efficiency (%). Hybrid NPs were prepared using the nanoprecipitation method. The results demonstrated that spherical were synthesized, and the rate of went up by increasing the polymer as well as decreasing the concentrations. The nanoformulation released in a sustained and controlled manner (17.39% in a period time of 48 h). Also, cytotoxicity evaluations showed that caused an increase in the efficacy of against human ovarian and cancer cells. Overall, the results of this study demonstrated that can be considered as a promising carrier for the delivery of hydrophobic anticancer drugs such as and the evaluation

摘要

控释药物递送系统的发展在提高抗癌药物疗效方面具有巨大潜力。本研究旨在开发并优化用于靶向递送抗癌药物的脂质-聚合物杂化纳米颗粒（）的制备。采用响应面法（）和中心复合设计（）来评估和优化脂质、聚合物和聚乙烯醇（）比例这三个自变量对纳米颗粒（）尺寸和药物包封率（%）的影响。使用纳米沉淀法制备杂化纳米颗粒。结果表明合成出了球形颗粒，并且通过增加聚合物以及降低浓度，包封率提高。该纳米制剂以持续且可控的方式释放（在48小时内释放17.39%）。此外，细胞毒性评估表明会导致对人卵巢癌和癌细胞的疗效增加。总体而言，本研究结果表明可被视为递送诸如等疏水性抗癌药物的有前景的载体以及评估

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72e/8842616/13349788ec20/ijpr-20-213-g012.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72e/8842616/d04dce4b7e84/ijpr-20-213-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72e/8842616/8ffcb26bb186/ijpr-20-213-g008.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72e/8842616/b0f2c7e89eb4/ijpr-20-213-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72e/8842616/9ee63a14f60e/ijpr-20-213-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72e/8842616/13349788ec20/ijpr-20-213-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72e/8842616/5368323b0aa0/ijpr-20-213-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72e/8842616/babc0beec64f/ijpr-20-213-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72e/8842616/9640cffac783/ijpr-20-213-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72e/8842616/48bf162ca485/ijpr-20-213-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72e/8842616/1e450af70116/ijpr-20-213-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72e/8842616/7f7e4699d14a/ijpr-20-213-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72e/8842616/d04dce4b7e84/ijpr-20-213-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72e/8842616/8ffcb26bb186/ijpr-20-213-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72e/8842616/0f19668d523b/ijpr-20-213-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72e/8842616/b0f2c7e89eb4/ijpr-20-213-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72e/8842616/9ee63a14f60e/ijpr-20-213-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e72e/8842616/13349788ec20/ijpr-20-213-g012.jpg

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