Department of Chemical Engineering, Islamic Azad University, Shahrood Branch, Shahrood, Iran.
School of Chemistry, Physics and Mechanical Engineering, Science and Engineering Faculty, Molecular Design and Synthesis Discipline, Queensland University of Technology, Brisbane, Australia.
J Drug Target. 2021 Feb;29(2):131-154. doi: 10.1080/1061186X.2020.1812614. Epub 2020 Sep 8.
Mesoporous silica nanoparticles (MSNPs) are a particular example of innovative nanomaterials for the development of drug delivery systems. MSNPs have recently received more attention for biological and pharmaceutical applications due to their capability to deliver therapeutic agents. Due to their unique structure, they can function as an effective carrier for the delivery of therapeutic agents to mitigate diseases progress, reduce inflammatory responses and consequently improve cancer treatment. The potency of MSNPs for the diagnosis and management of various diseases has been studied. This literature review will take an in-depth look into the properties of various types of MSNPs (e.g. shape, particle and pore size, surface area, pore volume and surface functionalisation), and discuss their characteristics, in terms of cellular uptake, drug delivery and release. MSNPs will then be discussed in terms of their therapeutic applications (passive and active tumour targeting, theranostics, biosensing and immunostimulative), biocompatibility and safety issues. Also, emerging trends and expected future advancements of this carrier will be provided.
介孔硅纳米粒子（MSNPs）是用于开发药物输送系统的创新型纳米材料的一个特殊例子。由于其传递治疗剂的能力，MSNPs 最近在生物和制药应用方面受到了更多关注。由于其独特的结构，它们可以作为治疗剂传递的有效载体，以减轻疾病进展、减少炎症反应，从而改善癌症治疗效果。MSNPs 对各种疾病的诊断和治疗的潜力已经得到了研究。本文献综述将深入探讨各种类型的 MSNPs（例如形状、颗粒和孔径、表面积、孔体积和表面功能化）的特性，并讨论它们的特性，包括细胞摄取、药物输送和释放。然后将讨论 MSNPs 在治疗应用方面的应用（被动和主动肿瘤靶向、治疗诊断、生物传感和免疫刺激）、生物相容性和安全性问题。此外，还将提供该载体的新兴趋势和预期的未来发展。
