Taylor Alicia A, Tsuji Joyce S, McArdle Margaret E, Adams William J, Goodfellow William L
Exponent, Inc., 475 14th Street, Suite 400, Oakland, CA, 94612, USA.
Exponent, Inc., 15375 SE 30th Place, Suite 250, Bellevue, WA, 98027, USA.
Risk Anal. 2023 Feb;43(2):211-218. doi: 10.1111/risa.13906. Epub 2022 Feb 22.
The U.S. Environmental Protection Agency's (EPA) Integrated Risk Information System (IRIS) database, the authoritative source of U.S. risk assessment toxicity factors, currently lacks an oral reference dose (RfD) for copper. In the absence of such a value, various health-based reference values for copper are available for use in risk assessment. We summarize the scientific bases and differences in assumptions among key reference values for ingested copper to guide selection of appropriate values for risk assessment. A comprehensive review of the scientific literature best supports the oral RfD of 0.04 mg/kg body weight/day derived by EPA from their Drinking Water Action Level. This value is based on acute gastrointestinal effects but is further supported by broader analysis of copper deficiency and toxicity.
美国环境保护局（EPA）的综合风险信息系统（IRIS）数据库是美国风险评估毒性因子的权威来源，目前缺乏铜的口服参考剂量（RfD）。在没有此类数值的情况下，有各种基于健康的铜参考值可用于风险评估。我们总结了摄入铜的关键参考值之间的科学依据和假设差异，以指导选择适用于风险评估的数值。对科学文献的全面审查最有力地支持了EPA根据其饮用水行动水平得出的0.04毫克/千克体重/天的口服RfD。该数值基于急性胃肠道效应，但通过对铜缺乏和毒性的更广泛分析得到了进一步支持。
