Niho M
Int J Pediatr Otorhinolaryngol. 1986 Feb;11(1):79-95. doi: 10.1016/s0165-5876(86)80031-3.
In order to study the manifestation and genesis of cholesterol deposits in the temporal bone and the paranasal sinuses, 137 temporal bones and 3 paranasal sinuses with deposits were examined. For histological study, 1036 specimens were obtained from temporal bones, and 16 specimens were obtained from paranasal sinuses. Several stages of a progressive foreign body reaction, including the appearance of histiocytes, granuloma formation and the development of granulation into scar tissue, were observed depending on the size and form of the crystals. Many large deposits were found in the temporal bones of patients with chronic non-suppurative lesions. Blue eardrum and hemotympanum were seen in the last stage of this foreign body reaction in these patients. Small deposits were found in the temporal bones and the paranasal sinuses of patients with chronic suppurative lesions. Most of these deposits were found in the obstructed parts. The pathogenesis of the cholesterol deposits is suspected to be fatty degeneration of the connective tissue.
为了研究颞骨和鼻窦中胆固醇沉积的表现及成因，对137块有沉积物的颞骨和3个有沉积物的鼻窦进行了检查。为进行组织学研究，从颞骨获取了1036个标本，从鼻窦获取了16个标本。根据晶体的大小和形态，观察到了渐进性异物反应的几个阶段，包括组织细胞的出现、肉芽肿形成以及肉芽组织发展为瘢痕组织。在慢性非化脓性病变患者的颞骨中发现了许多大的沉积物。在这些患者异物反应的最后阶段可见蓝鼓膜和血鼓室。在慢性化脓性病变患者的颞骨和鼻窦中发现了小的沉积物。这些沉积物大多位于阻塞部位。胆固醇沉积的发病机制被怀疑是结缔组织的脂肪变性。
