Amrita Vishwa Vidyapeetham, Kochi, Kerala, India.
Department of Pathology, Regional Cancer Centre, Trivandrum, Kerala, India.
Clin Nucl Med. 2022 May 1;47(5):e389-e392. doi: 10.1097/RLU.0000000000004102.
Multiple endocrine neoplasia 1 (MEN1) syndrome is an autosomal dominant syndrome comprising a triad of pancreatic, pituitary, and parathyroid tumors. Adrenal cortical carcinoma occurs rarely in MEN1 syndrome. Here, we have presented a case of a 62-year-old woman with adrenal mass and elevated serum parathormone levels, who underwent 68Ga-DOTANOC PET/CT. 68Ga-DOTANOC PET/CT showed intense tracer concentration in the left adrenal mass and lesions in the liver, pancreas, and peritoneum. Biopsy of the peritoneal deposit revealed metastatic adrenocortical carcinoma, and further genetic testing showed MEN1 mutation.
多发性内分泌腺瘤 1 型（MEN1）综合征是一种常染色体显性综合征，包括胰腺、垂体和甲状旁腺瘤的三联征。MEN1 综合征中肾上腺皮质癌很少见。在这里，我们报告了一例 62 岁女性因肾上腺肿块和血清甲状旁腺激素水平升高就诊，行 68Ga-DOTANOC PET/CT 检查。68Ga-DOTANOC PET/CT 显示左肾上腺肿块和肝脏、胰腺及腹膜内病变处有强烈的示踪剂浓度。腹膜沉积物活检显示转移性肾上腺皮质癌，进一步的基因检测显示 MEN1 突变。
