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一例儿童肾上腺皮质癌罕见病例报告及文献复习

Report of a rare case of childhood adrenocortical carcinoma and literature review.

作者信息

Wu Zhihuang, Qiu Lianyu, Zhang Minjie, Chen Guoqiang

机构信息

Department of Urology, Master's Degree, The Second Hospital of Longyan, Fujian, China.

Department of Pediatrics, Bachelor's Degree, The Second Hospital of Longyan, Fujian, China.

出版信息

Urol Case Rep. 2025 Jun 23;61:103113. doi: 10.1016/j.eucr.2025.103113. eCollection 2025 Jul.

DOI:10.1016/j.eucr.2025.103113
PMID:40677937
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12269434/
Abstract

Adrenocortical carcinoma (ACC)in children is rare, and its nonspecific clinical presentation renders early diagnosis challenging. Surgery remains the primary therapeutic approach. A multidisciplinary, multimodal treatment strategy and long-term follow-up are essential to improve prognosis. A retrospective analysis was conducted on the clinical data of a child diagnosed with ACC at our hospital, including symptoms, signs, imaging findings, surgical procedures, pathological results, and postoperative follow-up, We also perform a literature review to increase disease awareness and provide references for similar clinical cases in the future.

摘要

儿童肾上腺皮质癌(ACC)较为罕见,其非特异性临床表现使得早期诊断具有挑战性。手术仍然是主要的治疗方法。多学科、多模式的治疗策略以及长期随访对于改善预后至关重要。对我院一名诊断为ACC的儿童的临床资料进行了回顾性分析,包括症状、体征、影像学检查结果、手术过程、病理结果及术后随访情况。我们还进行了文献综述,以提高对该疾病的认识,并为未来类似临床病例提供参考。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f429/12269434/becf7f7bfafa/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f429/12269434/24735c0c3698/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f429/12269434/6c6938ff6dca/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f429/12269434/becf7f7bfafa/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f429/12269434/24735c0c3698/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f429/12269434/6c6938ff6dca/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f429/12269434/becf7f7bfafa/gr3.jpg

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本文引用的文献

1
[Interpretation of the 5th edition WHO classification of adrenal cortical tumors].[世界卫生组织肾上腺皮质肿瘤分类第5版解读]
Zhonghua Bing Li Xue Za Zhi. 2024 Jan 8;53(1):16-21. doi: 10.3760/cma.j.cn112151-20230809-00058.
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The SCARE 2023 guideline: updating consensus Surgical CAse REport (SCARE) guidelines.SCARE 2023 指南:更新共识外科病例报告(SCARE)指南。
Int J Surg. 2023 May 1;109(5):1136-1140. doi: 10.1097/JS9.0000000000000373.
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Application of TFE3 Immunophenotypic and TFE3 mRNA Expressions in Diagnosis and Prognostication of Adrenal Cortical Neoplasms and Distinction From Kidney Tumors.
TFE3免疫表型及TFE3 mRNA表达在肾上腺皮质肿瘤诊断、预后评估及与肾肿瘤鉴别中的应用
Appl Immunohistochem Mol Morphol. 2023 Jan 1;31(1):9-16. doi: 10.1097/PAI.0000000000001090. Epub 2022 Nov 21.
4
Dehydroepiandrosterone, Cancer, and Aging.脱氢表雄酮、癌症与衰老
Aging Dis. 2022 Apr 1;13(2):423-432. doi: 10.14336/AD.2021.0913. eCollection 2022 Apr.
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Overview of the 2022 WHO Classification of Adrenal Cortical Tumors.《2022 年世界卫生组织肾上腺皮质肿瘤分类概述》。
Endocr Pathol. 2022 Mar;33(1):155-196. doi: 10.1007/s12022-022-09710-8. Epub 2022 Mar 14.
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68Ga-DOTANOC PET/CT in Multiple Endocrine Neoplasia 1 With Associated Adrenocortical Carcinoma.68Ga-DOTANOC PET/CT 在多发性内分泌肿瘤 1 型伴发肾上腺皮质癌中的应用。
Clin Nucl Med. 2022 May 1;47(5):e389-e392. doi: 10.1097/RLU.0000000000004102.
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Short-Term Effects of Temperature and Thyrotropin-Releasing Hormone Stimulation on Adrenocorticotropin Stability in Horses.温度和促甲状腺激素释放激素刺激对马促肾上腺皮质激素稳定性的短期影响
Animals (Basel). 2022 Jan 28;12(3):324. doi: 10.3390/ani12030324.
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European Society of Endocrine Surgeons (ESES) and European Network for the Study of Adrenal Tumours (ENSAT) recommendations for the surgical management of adrenocortical carcinoma.欧洲内分泌外科医师学会(ESES)和欧洲肾上腺肿瘤研究网络(ENSAT)关于肾上腺皮质癌手术治疗的建议。
Br J Surg. 2017 Mar;104(4):358-376. doi: 10.1002/bjs.10414.
9
Adrenal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.肾上腺癌:ESMO 诊断、治疗及随访临床实践指南
Ann Oncol. 2012 Oct;23 Suppl 7:vii131-8. doi: 10.1093/annonc/mds231.
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Molecular markers and the pathogenesis of adrenocortical cancer.分子标志物与肾上腺皮质癌的发病机制
Oncologist. 2008 May;13(5):548-61. doi: 10.1634/theoncologist.2007-0243.