Larina G I, Karpovich L G, Levkovich E N
Vopr Virusol. 1978 Mar-Apr(2):207-11.
Most arbovirus infections are characterized by multiplication of the causative agent in tissues of the reticuloendothelial system. In this study, the effect of some viruses of the tick-borne encephalitis complex on the reaction of B-cells of mouse spleens was investigated by the hemolysin-producing activity (number of plaque-forming cells). To equal small doses of a highly virulent (Pan), naturally attenuated (Tp-21) and experimentally attenuated (Tp-21-237) strains the immunocompetent cells of mouse spleens responded by active reactions. The immunocompetence of these cells after primary introduction of the antigens persists and revaccination response occurs after a secondary infection with the same viruses. Under these experimental conditions the active response of spleen cells to the antigenic stimulation correlates with formation of the specific resistance and does not correlate with the level of antihemagglutinins in the blood.
大多数虫媒病毒感染的特征是病原体在网状内皮系统的组织中增殖。在本研究中，通过溶血素产生活性（空斑形成细胞数量）研究了蜱传脑炎复合体的一些病毒对小鼠脾脏B细胞反应的影响。对于等量小剂量的高毒力（Pan）、自然减毒（Tp-21）和实验减毒（Tp-21-237）毒株，小鼠脾脏的免疫活性细胞通过活跃反应做出应答。初次引入抗原后这些细胞的免疫活性持续存在，再次感染相同病毒后会出现再次接种反应。在这些实验条件下，脾脏细胞对抗原刺激的活跃反应与特异性抵抗力的形成相关，而与血液中抗血凝素的水平无关。
