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Imeglimin to the Rescue: Enhanced CHOP/GADD34/eIF2α Signaling Axis Promotes β-Cell Survival.

作者信息

Jo Seokwon, Alejandro Emilyn U

出版信息

Diabetes. 2022 Mar 1;71(3):376-378. doi: 10.2337/dbi21-0035.

DOI:10.2337/dbi21-0035
PMID:35196391
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8893936/
Abstract
摘要

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Imeglimin to the Rescue: Enhanced CHOP/GADD34/eIF2α Signaling Axis Promotes β-Cell Survival.依美格列明来救援:增强的CHOP/GADD34/eIF2α信号轴促进β细胞存活。
Diabetes. 2022 Mar 1;71(3):376-378. doi: 10.2337/dbi21-0035.
2
Nck in a complex containing the catalytic subunit of protein phosphatase 1 regulates eukaryotic initiation factor 2alpha signaling and cell survival to endoplasmic reticulum stress.包含蛋白磷酸酶1催化亚基的复合物中的Nck调节真核起始因子2α信号传导及细胞对内质网应激的存活反应。
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UVB-induced eIF2α phosphorylation in keratinocytes depends on decreased ATF4, GADD34 and CReP expression levels.UVB 诱导角质细胞中 eIF2α 的磷酸化依赖于 ATF4、GADD34 和 CReP 表达水平的降低。
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引用本文的文献

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Imeglimin systematic review: a novel therapeutic approach for type 2 diabetes-unveiling benefits on β-cell function, insulin sensitivity, and potential long-term glycaemic control (HbA1c).依美格列明系统评价:2型糖尿病的一种新型治疗方法——揭示对β细胞功能、胰岛素敏感性和潜在长期血糖控制(糖化血红蛋白)的益处
Eur J Clin Pharmacol. 2025 Sep 4. doi: 10.1007/s00228-025-03902-x.
2
Diabetes mellitus and the key role of endoplasmic reticulum stress in pancreatic β cells.糖尿病与内质网应激在胰腺β细胞中的关键作用。
Nat Rev Endocrinol. 2025 Jun 4. doi: 10.1038/s41574-025-01129-5.
3
Imeglimin enhances glucagon secretion through an indirect mechanism and improves fatty liver in high-fat, high-sucrose diet-fed mice.依格列净通过间接机制增强胰高血糖素分泌,并改善高脂肪、高蔗糖饮食喂养的小鼠的脂肪肝。
J Diabetes Investig. 2024 Sep;15(9):1177-1190. doi: 10.1111/jdi.14249. Epub 2024 Jun 14.
4
Mechanism of Decision Making between Autophagy and Apoptosis Induction upon Endoplasmic Reticulum Stress.内质网应激时自噬和凋亡诱导之间的决策机制
Int J Mol Sci. 2024 Apr 15;25(8):4368. doi: 10.3390/ijms25084368.

本文引用的文献

1
Imeglimin Ameliorates β-Cell Apoptosis by Modulating the Endoplasmic Reticulum Homeostasis Pathway.依格列净通过调节内质网稳态通路改善β细胞凋亡。
Diabetes. 2022 Mar 1;71(3):424-439. doi: 10.2337/db21-0123.
2
Imeglimin Hydrochloride: First Approval.盐酸伊格列净:首次批准。
Drugs. 2021 Sep;81(14):1683-1690. doi: 10.1007/s40265-021-01589-9.
3
Imeglimin preserves islet β-cell mass in Type 2 diabetic ZDF rats.依格列净可保护 2 型糖尿病 ZDF 大鼠胰岛β细胞质量。
Endocrinol Diabetes Metab. 2020 Nov 7;4(2):e00193. doi: 10.1002/edm2.193. eCollection 2021 Apr.
4
What Is the Sweetest UPR Flavor for the β-cell? That Is the Question.哪种 UPR 口味最受β细胞欢迎?这是个问题。
Front Endocrinol (Lausanne). 2021 Jan 19;11:614123. doi: 10.3389/fendo.2020.614123. eCollection 2020.
5
Efficacy and Safety of Imeglimin Monotherapy Versus Placebo in Japanese Patients With Type 2 Diabetes (TIMES 1): A Double-Blind, Randomized, Placebo-Controlled, Parallel-Group, Multicenter Phase 3 Trial.在日本 2 型糖尿病患者中,伊格列净单药治疗与安慰剂相比的疗效和安全性(TIMES 1):一项双盲、随机、安慰剂对照、平行分组、多中心 3 期临床试验。
Diabetes Care. 2021 Apr;44(4):952-959. doi: 10.2337/dc20-0763. Epub 2021 Feb 11.
6
Mechanism of action of Imeglimin: A novel therapeutic agent for type 2 diabetes.依格列净作用机制:一种新型 2 型糖尿病治疗药物。
Diabetes Obes Metab. 2021 Mar;23(3):664-673. doi: 10.1111/dom.14277. Epub 2020 Dec 29.
7
Impact of GADD34 on Apoptosis of Tonsillar Mononuclear Cells from IgA Nephropathy Patients by Regulating Eif2α Phosphorylation.GADD34通过调节Eif2α磷酸化对IgA肾病患者扁桃体单个核细胞凋亡的影响
Cell Physiol Biochem. 2018;50(6):2203-2215. doi: 10.1159/000495061. Epub 2018 Nov 9.
8
Biosynthesis, structure, and folding of the insulin precursor protein.胰岛素前体蛋白的生物合成、结构和折叠。
Diabetes Obes Metab. 2018 Sep;20 Suppl 2(Suppl 2):28-50. doi: 10.1111/dom.13378.
9
Imeglimin prevents human endothelial cell death by inhibiting mitochondrial permeability transition without inhibiting mitochondrial respiration.依美格列明通过抑制线粒体通透性转换而不抑制线粒体呼吸来防止人内皮细胞死亡。
Cell Death Discov. 2016 Jan 18;2:15072. doi: 10.1038/cddiscovery.2015.72. eCollection 2016.
10
Imeglimin lowers glucose primarily by amplifying glucose-stimulated insulin secretion in high-fat-fed rodents.在高脂喂养的啮齿动物中,依美格列敏主要通过增强葡萄糖刺激的胰岛素分泌来降低血糖。
Am J Physiol Endocrinol Metab. 2016 Aug 1;311(2):E461-70. doi: 10.1152/ajpendo.00009.2016. Epub 2016 Jul 12.