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无眼部手术史的单纯性翼状胬肉切除术后弥漫性角膜水肿:前部毒性综合征还是毒性角膜病?

Diffuse Corneal Edema after Uneventful Pterygium Surgery: Toxic Anterior Segment Syndrome or Toxic Keratopathy?

机构信息

İstanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, Department of Ophthalmology, İstanbul, Turkey

University of Health Sciences Turkey, Başakşehir Çam and Sakura City Hospital, Clinic of Ophthalmology, İstanbul, Turkey

出版信息

Turk J Ophthalmol. 2022 Feb 23;52(1):69-71. doi: 10.4274/tjo.galenos.2021.07717.

DOI:10.4274/tjo.galenos.2021.07717
PMID:35196843
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8876773/
Abstract

A 29-year-old woman was referred to our department for corneal edema after uneventful pterygium excision surgery with conjunctival autografting. She was prescribed topical dexamethasone and showed a complete response within 2 weeks of treatment. Specular microscopic examination revealed severe endothelial cell loss in the operated eye. Mild corneal haze causing a decrease in vision (20/50) was observed in long-term follow-up. This steroid-responsive complication was linked to two possible etiologies: mild toxic anterior segment syndrome or povidone-iodine (PVP-I) corneal toxicity. Surgeons should be careful during pterygium surgery to completely clear PVP-I and avoid any penetration into the anterior chamber to prevent possible serious complications. When diffuse corneal edema is encountered after pterygium surgery, intense steroid treatment should be prescribed as in the present case.

摘要

一位 29 岁女性在接受翼状胬肉切除联合结膜自体移植术后无明显异常,因角膜水肿被转至我科。她接受了局部地塞米松治疗,治疗 2 周内完全缓解。共焦显微镜检查显示手术眼内皮细胞严重丢失。在长期随访中发现轻度角膜混浊导致视力下降(20/50)。这种对类固醇有反应的并发症可能与两种病因有关:轻度毒性前节综合征或聚维酮碘(PVP-I)角膜毒性。在翼状胬肉手术中,外科医生应小心操作,以彻底清除 PVP-I 并避免任何穿透前房,以防止可能发生的严重并发症。如本例患者,当翼状胬肉手术后出现弥漫性角膜水肿时,应给予强的松龙治疗。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74cc/8876773/d6e6ab1bb79d/TJO-52-69-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74cc/8876773/1ee9ece7fedb/TJO-52-69-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74cc/8876773/d6e6ab1bb79d/TJO-52-69-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74cc/8876773/1ee9ece7fedb/TJO-52-69-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/74cc/8876773/d6e6ab1bb79d/TJO-52-69-g2.jpg

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本文引用的文献

1
Pterygium: epidemiology prevention and treatment.翼状胬肉:流行病学、预防与治疗
Community Eye Health. 2017;30(99):S5-S6.
2
Capsular bag irrigation using 0.025% povidone-iodine in balanced salt solution PLUS for the treatment of postoperative endophthalmitis.使用0.025%聚维酮碘平衡盐溶液PLUS进行囊袋冲洗治疗术后眼内炎。
Int Ophthalmol. 2018 Aug;38(4):1787-1790. doi: 10.1007/s10792-017-0645-9. Epub 2017 Jul 8.
3
Developments and current approaches in the treatment of pterygium.翼状胬肉治疗的进展与当前方法
Int Ophthalmol. 2017 Aug;37(4):1073-1081. doi: 10.1007/s10792-016-0358-5. Epub 2016 Sep 23.
4
Toxic anterior segment syndrome: common causes.毒性眼前节综合征:常见病因
J Cataract Refract Surg. 2010 Jul;36(7):1073-80. doi: 10.1016/j.jcrs.2010.01.030.
5
The toxic effect of different concentrations of povidone iodine on the rabbit's cornea.不同浓度聚维酮碘对兔角膜的毒性作用。
Cutan Ocul Toxicol. 2009;28(3):119-24. doi: 10.1080/15569520903080511.
6
Effect of complete epithelial debridement before riboflavin-ultraviolet-A corneal collagen crosslinking therapy.核黄素-紫外线A角膜胶原交联治疗前完全上皮清创的效果
J Cataract Refract Surg. 2008 Apr;34(4):657-61. doi: 10.1016/j.jcrs.2008.02.002.
7
Outbreak of toxic anterior segment syndrome associated with glutaraldehyde after cataract surgery.白内障手术后与戊二醛相关的毒性眼前节综合征暴发。
J Cataract Refract Surg. 2006 Oct;32(10):1696-701. doi: 10.1016/j.jcrs.2006.05.008.
8
Serious corneoscleral complications after pterygium excision with mitomycin C.翼状胬肉切除联合丝裂霉素C术后严重的角膜巩膜并发症
Br J Ophthalmol. 2002 Mar;86(3):357-8. doi: 10.1136/bjo.86.3.357.
9
Corneal endothelial cytotoxicity of diluted povidone--iodine.稀释聚维酮碘的角膜内皮细胞毒性
J Cataract Refract Surg. 2001 Jun;27(6):941-7. doi: 10.1016/s0886-3350(00)00750-1.
10
The effect of povidone iodine on the corneal endothelium.聚维酮碘对角膜内皮的作用。
Cornea. 2000 Jul;19(4):546-50. doi: 10.1097/00003226-200007000-00028.