Mary H. Weiser Food Allergy Center, University of Michigan, Ann Arbor, MI 48109, USA.
Department of Chemical Engineering, Texas Tech University, Lubbock, TX 79409, USA.
Immunotherapy. 2022 May;14(7):539-552. doi: 10.2217/imt-2021-0206. Epub 2022 Feb 24.
Epicutaneous immunotherapy (EPIT) with peanut has been demonstrated to be safe but efficacy may be limited by allergen uptake through the skin barrier. To enhance allergen uptake into the skin, the authors used peanut-coated microneedles and compared them with EPIT in a peanut allergy mouse model. Sensitized mice were treated with peanut-coated microneedles or peanut-EPIT and then challenged with peanut to determine protection. Treatment with peanut-coated microneedles was safe and showed enhanced desensitization to peanut compared with peanut-EPIT administered via a similar schedule. Protection was associated with reduced Th2 immune responses and mast cell accumulation in the intestine. Peanut-coated microneedles have the potential to present a safe method of improving allergen delivery for cutaneous immunotherapy.
经皮免疫疗法（EPIT）已被证实用于花生是安全的，但由于皮肤屏障对过敏原的摄取，疗效可能有限。为了增强过敏原进入皮肤，作者使用了涂有花生的微针，并在花生过敏小鼠模型中与 EPIT 进行了比较。致敏的小鼠用涂有花生的微针或花生-EPIT 治疗，然后用花生进行挑战以确定保护作用。涂有花生的微针治疗是安全的，与通过类似方案给予的花生-EPIT 相比，显示出增强的脱敏作用。保护作用与减少肠道中的 Th2 免疫反应和肥大细胞积累有关。涂有花生的微针有可能提供一种安全的方法，改善用于皮肤免疫疗法的过敏原传递。
