Chua Corrine Ying Xuan, Viswanath Dixita Ishani, Huston David P, Grattoni Alessandro
Department of Nanomedicine, Houston Methodist Research Institute, Houston, Tex.
New York Presbyterian Morgan Stanley Children's Hospital, Columbia University Irving Medical Center, New York, NY.
J Allergy Clin Immunol. 2024 Mar;153(3):572-575. doi: 10.1016/j.jaci.2024.01.004. Epub 2024 Jan 20.
Systemic immunotherapeutics have been a clinical staple in the treatment of cancer, infectious diseases, organ and cell transplantation, autoimmunity, and allergies. Although their utility remains unquestioned, systemic administration of these drugs is associated with limited efficacy, significant adverse off-target effects, transient activity, and the requirement for frequent repeated dosing. To this end, recent technological advancements have provided novel means for sustained drug delivery to specific tissues and targeted localized approaches for immunotherapeutics. In this article, we present various cutting-edge platform technologies, including implants, multireservoir systems, and scaffolds encapsulating immunomodulatory agents for local administration. Examples of their application in cancer, cell transplantation, allergy, and infectious diseases are discussed, highlighting the potential of such systems for innovative immunomodulatory intervention.
全身性免疫疗法一直是癌症、传染病、器官和细胞移植、自身免疫性疾病及过敏症治疗中的临床常用方法。尽管其效用毋庸置疑，但这些药物的全身给药存在疗效有限、显著的非靶向不良副作用、活性短暂以及需要频繁重复给药等问题。为此，最近的技术进步为向特定组织持续给药以及免疫疗法的靶向局部给药方法提供了新手段。在本文中，我们介绍了各种前沿平台技术，包括植入物、多储库系统以及封装免疫调节剂用于局部给药的支架。讨论了它们在癌症、细胞移植、过敏症和传染病中的应用实例，突出了此类系统在创新免疫调节干预方面的潜力。
