Clinical Research Development Center, Imam Reza Hospital, 48464Kermanshah University of Medical Sciences, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Department of Biochemistry, Faculty of Veterinary Medicine, Shiraz University, Shiraz, Iran.
J Int Med Res. 2022 Feb;50(2):3000605221078699. doi: 10.1177/03000605221078699.
To evaluate blood lipid profiles in patients with coronavirus disease 2019 (COVID-19), and to explore the association with disease severity.
This case-control study included patients with COVID-19, referred to two medical centers in Kermanshah, Iran (between July 2020 and December 2020), and healthy controls. Lipid profiles were evaluated in patients who were grouped according to severe (intensive care unit [ICU]), or less severe (outpatient), forms of COVID-19, and in healthy controls, and were compared among the three groups.
A total of 132 participants were included, comprising ICU ( = 49), outpatient ( = 48) and control ( = 35) groups. Mean cholesterol levels were lower in the patient groups than in controls; high-density lipoprotein cholesterol (HDL-C) levels were higher in the ICU group versus outpatients, and low-density lipoprotein cholesterol (LDL-C) levels were lower in the ICU group versus outpatients. The frequency of diabetes and hypertension was higher in the ICU group than in the outpatient group. Furthermore, LDL-C level was associated with disease severity (odds ratio 0.966, 95% confidence interval 0.944, 0.989).
Lipid profiles differ between severe and less severe forms of COVID-19. LDL-C level may be a useful indicator of COVID-19 severity.
评估 2019 年冠状病毒病（COVID-19）患者的血脂谱，并探讨其与疾病严重程度的关系。
本病例对照研究纳入了 2020 年 7 月至 12 月期间在伊朗克尔曼沙赫的两家医疗机构就诊的 COVID-19 患者和健康对照者。根据 COVID-19 的严重程度（重症监护病房[ICU]）或较轻程度（门诊）将患者分组，评估血脂谱，并在三组之间进行比较。
共纳入 132 名参与者，包括 ICU 组（ = 49）、门诊组（ = 48）和对照组（ = 35）。与对照组相比，患者组的胆固醇水平较低；与门诊组相比，ICU 组的高密度脂蛋白胆固醇（HDL-C）水平较高，而 LDL-C 水平较低。与门诊组相比，ICU 组的糖尿病和高血压患病率更高。此外，LDL-C 水平与疾病严重程度相关（比值比 0.966，95%置信区间 0.944，0.989）。
严重和较轻形式的 COVID-19 患者的血脂谱存在差异。LDL-C 水平可能是 COVID-19 严重程度的一个有用指标。
