Abergel R P, Lyons R F, White R A, Lask G, Matsuoka L Y, Dwyer R M, Uitto J
J Am Acad Dermatol. 1986 May;14(5 Pt 1):810-4. doi: 10.1016/s0190-9622(86)70098-4.
Skin incisions 6 mm in length were made on the backs of hairless mice. Control wounds were closed with interrupted 5-0 Prolene sutures, and experimental wounds were approximated and closed by laser welding using a Nd:YAG laser. The wounds were examined daily, and specimens were excised at weekly intervals for histopathologic study, transmission electron microscopy, tensile strength determination, and type I collagen-specific messenger ribonucleic acid measurements. The laser-welded wounds demonstrated rapid healing. Histologic study showed a functional scar tissue at day 7 and a minimal residue of the original wound at day 14. Tensile strength of the control and experimental wounds was similar at all time points. The levels of collagen-specific messenger ribonucleic acid were significantly higher in the sutured group in comparison with the laser group or with normal control skin. This study suggests that laser welding might have advantages over suturing, since the former is sterile and nontactile, does not require introduction of foreign material into the wound, and provides subjectively improved cosmetic results.
在无毛小鼠背部制作6毫米长的皮肤切口。对照伤口用5-0普理灵缝线间断缝合，实验伤口使用Nd:YAG激光进行近似并焊接闭合。每天检查伤口，每周间隔切除标本进行组织病理学研究、透射电子显微镜检查、拉伸强度测定和I型胶原特异性信使核糖核酸测量。激光焊接的伤口显示出快速愈合。组织学研究显示，在第7天形成功能性瘢痕组织，在第14天原始伤口残留极少。在所有时间点，对照伤口和实验伤口的拉伸强度相似。与激光组或正常对照皮肤相比，缝合组中胶原特异性信使核糖核酸水平显著更高。本研究表明，激光焊接可能比缝合具有优势，因为前者是无菌且无触感的，不需要将异物引入伤口，并且在主观上能提供更好的美容效果。
