Department of General Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Department of Ophthalmology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
BMC Ophthalmol. 2022 Feb 23;22(1):90. doi: 10.1186/s12886-022-02313-1.
Patients with psoriatic arthritis (PsA) may develop uveitis, a potentially serious ocular complication. PsA-related uveitis may result in significant morbidity and even vision loss if underdiagnosed or under-treated. We presented a case with long-standing recurrent uveitis and retinal vasculitis successfully managed by fortified systemic immunomodulators for systemic PsA.
A 47-year-old woman was referred under the impression of acute anterior uveitis in her right eye in recent one month. Ocular examinations showed panuveitis in both eyes with intense vitreous opacity in her right eye. Fundus fluorescence angiography revealed retinal vasculitis in both eyes. Systemic surveys excluded the possibility of infection but showed an elevated inflammation marker. With intensive immunosuppressive treatment, inflammation resolved and the vision improved.
Our case highlights not only the importance of intensified systemic therapy in treating PsA-related uveitis but the importance of multidisciplinary collaboration. Recurrent uveitis may be an indicator of disease activity prior to other inflammatory markers.
患有银屑病关节炎（PsA）的患者可能会发生葡萄膜炎，这是一种潜在的严重眼部并发症。如果漏诊或治疗不当，PsA 相关的葡萄膜炎可能导致严重的发病率，甚至视力丧失。我们报告了一例长期反复发作的葡萄膜炎和视网膜血管炎的病例，通过强化全身免疫调节剂成功治疗了全身型银屑病关节炎。
一名 47 岁女性，因右眼近期一个月内出现急性前葡萄膜炎被转诊。眼部检查显示双眼全葡萄膜炎，右眼玻璃体混浊明显。眼底荧光血管造影显示双眼视网膜血管炎。全身检查排除了感染的可能性，但显示炎症标志物升高。经过强化免疫抑制治疗，炎症得到缓解，视力有所改善。
我们的病例不仅强调了强化全身治疗治疗与银屑病关节炎相关的葡萄膜炎的重要性，还强调了多学科合作的重要性。反复发作的葡萄膜炎可能是其他炎症标志物之前疾病活动的指标。
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