Skolik Stephanie, Willermain François, Caspers Laure E
Department of Ophthalmology, Marshall University, Huntington, WV, USA.
Ocul Immunol Inflamm. 2005 Dec;13(6):483-5. doi: 10.1080/09273940590951115.
Rifabutin-associated uveitis has been reported frequently in AIDS patients and more rarely in immunocompetent patients. It is characterized clinically by anterior acute uveitis. Only a few poorly documented cases of rifabutin-induced panuveitis with retinal vasculitis have been reported. Here, we report four cases of rifabutin-associated panuveitis with retinal vasculitis.
We describe four patients with active tuberculosis, treated with a multidrug regimen including rifabutin for at least 1.5 months before presentation. The first patient was immunocompetent, the three others had AIDS and were undergoing triple anti-HIV therapy. Three patients were women with a low body weight. All four patients presented with panuveitis and retinal vasculitis. Interruption of the drug rapidly reduced the ocular inflammation in all cases.
Four cases of rifabutin-associated panuveitis with retinal vasculitis are reported in patients with active pulmonary tuberculosis. Immunogenicity of Mycobacterium tuberculosis as well as the very low weight of the patients might be implicated in the development of this unusual form of rifabutin-associated uveitis.
利福布汀相关性葡萄膜炎在艾滋病患者中经常被报道，而在免疫功能正常的患者中则较为罕见。其临床特征为前部急性葡萄膜炎。仅有少数记录不完整的利福布汀诱发的伴有视网膜血管炎的全葡萄膜炎病例被报道。在此，我们报告4例利福布汀相关性全葡萄膜炎伴视网膜血管炎病例。
我们描述了4例活动性结核病患者，在出现症状前接受了包括利福布汀在内的多药联合治疗至少1.5个月。第1例患者免疫功能正常，其他3例患有艾滋病且正在接受三联抗逆转录病毒治疗。3例患者为体重较轻的女性。所有4例患者均表现为全葡萄膜炎和视网膜血管炎。停药后所有病例的眼部炎症均迅速减轻。
我们报告了4例活动性肺结核患者发生利福布汀相关性全葡萄膜炎伴视网膜血管炎的病例。结核分枝杆菌的免疫原性以及患者的低体重可能与这种不寻常的利福布汀相关性葡萄膜炎的发生有关。
