Moshkovsky Ana R, Kirschner Marc W
Department of Systems Biology, Harvard Medical School, Boston, MA 02115.
Department of Systems Biology, Harvard Medical School, Boston, MA 02115
Proc Natl Acad Sci U S A. 2022 Mar 1;119(9). doi: 10.1073/pnas.2108408119.
Axin is one of two essential scaffolds in the canonical Wnt pathway that converts signals at the plasma membrane to signals inhibiting the degradation of β-catenin, leading to its accumulation and specific gene activation. In vertebrates, there are two forms of Axin, Axin1 and Axin2, which are similar at the protein level and genetically redundant. We show here that differential regulation of the two genes on the transcriptional and proteostatic level confers differential responsiveness that can be used in tissue-specific regulation. Such subtle features may distinguish other redundant gene pairs that are commonly found in vertebrates through gene knockout experiments.
Axin是经典Wnt信号通路中两个重要的支架蛋白之一，它能将质膜上的信号转化为抑制β-连环蛋白降解的信号，导致其积累并激活特定基因。在脊椎动物中，有两种形式的Axin，即Axin1和Axin2，它们在蛋白质水平上相似且在遗传上功能冗余。我们在此表明，这两个基因在转录和蛋白质稳态水平上的差异调节赋予了不同的反应性，可用于组织特异性调节。这种微妙的特征可能会区分通过基因敲除实验在脊椎动物中常见的其他冗余基因对。
