Division of Gastroenterology and Hepatology, Department of Medicine, University of Illinois Chicago, Chicago, IL, USA.
Department of Microbiology and Immunology, University of Illinois Chicago, Chicago, IL, USA.
Gut Microbes. 2023 Dec;15(2):2286674. doi: 10.1080/19490976.2023.2286674. Epub 2023 Nov 27.
Classically, Axin1 is considered a regulator of Wnt/β-catenin signaling. However, Axin1's roles in host-microbial interactions have been unknown. Our recent study has demonstrated that deletion of intestinal epithelial Axin1 in epithelial cells and Paneth cells protects the host against colitis by enhancing . Loss of intestinal epithelial or Paneth cell Axin1 results in increased Wnt/β-catenin signaling, proliferation, and cell migration. This is associated with morphologically altered goblet and Paneth cells, including increased Muc2 and decreased lysozyme. Axin1 deletion specifically enriched . in Axin1 knockout mice is the driver of protection against DSS-induced inflammation. Here, we feature several significant conceptual changes, such as differences between Axin1 and Axin2, Axin1 in innate immunity and microbial homeostasis, and Axin1 reduction of . We discuss an important trend in the field related to Paneth cells and tissue-specific Axin1 manipulation of microbiome in health and inflammation.
经典地，Axin1 被认为是 Wnt/β-连环蛋白信号的调节剂。然而，Axin1 在宿主-微生物相互作用中的作用尚不清楚。我们最近的研究表明，上皮细胞和潘氏细胞中肠上皮 Axin1 的缺失通过增强. 来保护宿主免受结肠炎。肠上皮或潘氏细胞 Axin1 的缺失导致 Wnt/β-连环蛋白信号、增殖和细胞迁移增加。这与形态改变的杯状细胞和潘氏细胞有关，包括 Muc2 增加和溶菌酶减少。Axin1 缺失特异性富集. 在 Axin1 敲除小鼠中是对抗 DSS 诱导的炎症的驱动力。在这里，我们介绍了几个重要的概念变化，例如 Axin1 和 Axin2 之间的差异、先天免疫和微生物动态平衡中的 Axin1 以及 Axin1 减少. 我们讨论了与潘氏细胞和组织特异性 Axin1 操纵微生物组在健康和炎症中的相关领域的一个重要趋势。
