Age-Specific Distribution of Serum Anti-Mullerian Hormone and Antral Follicle Count in Indian Infertile Women.

BACKGROUND

Ovarian reserve declines with age. However, there are considerable ethnic differences in the decline of ovarian reserve between individuals.

AIM

This study aimed to make age-specific percentile charts of anti-Mullerian hormone (AMH) and antral follicle count (AFC) in Indian infertile women and to find the proportion of young women with low ovarian reserve.

SETTING AND DESIGN

This was a retrospective data analysis of AMH and AFC of 5525 infertile women from August 2015 to December 2018.

MATERIALS AND METHODS

Infertile women aged 20- 44 years, with body mass index 18-32 kg/m and having both ovaries were included in the study. Women with pituitary/adrenal disorders, malignancy, total AFC >40, tuberculosis, endometriosis, autoimmune disorders, smoking, chemotherapy, radiotherapy and recent ovarian surgery were excluded from the study.

STATISTICAL ANALYSIS

Comparison between groups was done by Chi-square test.

RESULTS

About 14.5% of women <35 years and 50.5% of women >35 years had low AMH values (<1.1 ng/ml). In addition, 5.6% of women <35 years and 23.6% of women >35 years had a low AFC of ≤5. In this study, 55.7% of women who had low AMH and 50.7% who had low AFC were <35 years of age. The median AMH values were 4.23 ng/mL in 20-25 years' age group, 3.48 ng/mL in women aged 26-30 years, 2.43 ng/mL in women aged 31-35 years, 1.28 ng/mL in women aged 36-40 years and0.52 ng/mL in 40-44 years' age group. The median AFCs were 20, 18, 14, 10 and 6 for each of the age groups, respectively.

CONCLUSION

This study suggests that approximately more than half of the infertile women who were tested to have low ovarian reserve were <35 years of age.