Patel Niket H, Bhadarka Harsha K, Patel Nayana H, Patel Molina Niket
Departments of Reproductive Medicine and Akanksha Hospital and Research Institute, Anand, Gujarat, India.
J Hum Reprod Sci. 2021 Oct-Dec;14(4):443-445. doi: 10.4103/jhrs.jhrs_56_21. Epub 2021 Dec 31.
Primary Ovarian Insufficiency (POI) or Diminished Ovarian Reserve (DOR) are the two conditions that affects women leading to infertility due to the lack of follicular growth and ovulation. Egg / Oocyte donation remains an option for these patients. However, with the development in Reproductive medicine various novel technologies like Ovarian Cryopreservation, Fragmentation, activation with drug treatment or even drug free autotransplantation enables the possibility of activating the pool of primordial follicles that can lead to successful pregnancy outcomes. Here, we report a case of women with POI, in which drug free activation of follicles was performed, followed by autotransplantation, which resulted in successful pregnancy. This is first case report from India that shows the procedure works and can be tried for women with POI.
原发性卵巢功能不全（POI）或卵巢储备功能减退（DOR）是导致女性因卵泡生长和排卵缺乏而不孕的两种情况。卵子/卵母细胞捐赠仍然是这些患者的一种选择。然而，随着生殖医学的发展，各种新技术如卵巢冷冻保存、碎片化、药物治疗激活甚至无药物自体移植，使得激活原始卵泡库从而实现成功妊娠结局成为可能。在此，我们报告一例原发性卵巢功能不全的女性病例，其中对卵泡进行了无药物激活，随后进行自体移植，最终成功妊娠。这是来自印度的首例病例报告，表明该手术可行，且可用于原发性卵巢功能不全的女性。
