Ponnighaus J M, Fine P E
Int J Lepr Other Mycobact Dis. 1986 Mar;54(1):25-37.
This paper describes a comparison between BCG alone and two different doses of killed Mycobacterium leprae, with or without BCG, in stimulating skin-test sensitivity to two different soluble antigens prepared from M. leprae. Skin test conversion was assessed three months after vaccination. Significant rates of skin test conversion were stimulated by each of the vaccines to both skin test antigens, but the observed conversion rates differed markedly as measured by the two antigens. All of the vaccines caused ulcers at the site of injection in most subjects, and these local reactions are described. A combined vaccine containing 0.03 mg BCG plus 5 X 10(7) killed M. leprae induced high rates of "conversion" to both skin tests but caused local reactions slightly larger than those caused by BCG alone. The implications of these findings for selection of an optimal vaccine formulation for use in large-scale preventive trials are discussed.
本文描述了单独使用卡介苗（BCG）以及两种不同剂量的灭活麻风杆菌（无论是否联合BCG）在刺激皮肤对由麻风杆菌制备的两种不同可溶性抗原的试验敏感性方面的比较。在接种疫苗三个月后评估皮肤试验的转变情况。每种疫苗都能刺激对两种皮肤试验抗原的皮肤试验转变率达到显著水平，但通过两种抗原测量时观察到的转变率明显不同。在大多数受试者中，所有疫苗都在注射部位引起溃疡，并对这些局部反应进行了描述。一种含有0.03毫克BCG加5×10⁷个灭活麻风杆菌的联合疫苗，对两种皮肤试验都诱导了高“转变”率，但引起的局部反应略大于单独使用BCG所引起的反应。讨论了这些发现对于选择用于大规模预防性试验的最佳疫苗配方的意义。
