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乌司他丁治疗重症急性酒精性胰腺炎的病例系列研究。

Ulinastatin in the Management of Severe Acute Alcoholic Pancreatitis: A Case Series.

机构信息

Department of Critical Care Medicine, B &C Medical College Teaching Hospital & Research center, Birtamod, Jhapa, Nepal.

Department of General Surgery, B &C Medical College Teaching Hospital & Research center, Birtamod, Jhapa, Nepal.

出版信息

JNMA J Nepal Med Assoc. 2021 Dec 11;59(244):1302-1306. doi: 10.31729/jnma.4987.

DOI:10.31729/jnma.4987
PMID:35199800
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9200027/
Abstract

Severe acute alcoholic pancreatitis is a second common form of pancreatitis that requires intensive care unit care and has high morbidity and mortality due to lacking specific treatment. Management of alcoholic pancreatitis is generally non- specific and supportive. We hereby present a case-series of three patients that describes the successful treatment of severe acute alcoholic pancreatitis with ulinastatin and other supportive treatment. From this we want to emphasize that ulinastatin a protease inhibitor can be used in the treatment of alcoholic pancreatitis.

摘要

重症急性酒精性胰腺炎是胰腺炎的第二种常见形式，需要重症监护病房的护理，由于缺乏特定的治疗方法，其发病率和死亡率都很高。酒精性胰腺炎的治疗通常是非特异性的和支持性的。在此，我们报告了三例患者的病例系列，描述了使用乌司他丁和其他支持性治疗成功治疗重症急性酒精性胰腺炎。由此，我们想强调蛋白酶抑制剂乌司他丁可用于治疗酒精性胰腺炎。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f382/9200027/a7337f2af6bb/JNMA-59-244-1302-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f382/9200027/b35df48e81da/JNMA-59-244-1302-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f382/9200027/1eb56ec0e5e2/JNMA-59-244-1302-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f382/9200027/a7337f2af6bb/JNMA-59-244-1302-g3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f382/9200027/b35df48e81da/JNMA-59-244-1302-g1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f382/9200027/1eb56ec0e5e2/JNMA-59-244-1302-g2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f382/9200027/a7337f2af6bb/JNMA-59-244-1302-g3.jpg

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本文引用的文献

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Intensive management of severe acute pancreatitis.重症急性胰腺炎的强化管理。
Ann Transl Med. 2019 Nov;7(22):687. doi: 10.21037/atm.2019.10.58.
2
DIFFERENT SCORING SYSTEMS IN ACUTE ALCOHOLIC PANCREATITIS: WHICH ONE TO FOLLOW? AN ONGOING DILEMA.急性酒精性胰腺炎的不同评分系统：该遵循哪一个？一个持续存在的难题。
Arq Gastroenterol. 2019 Sep 30;56(3):280-285. doi: 10.1590/S0004-2803.201900000-53. eCollection 2019.
3
Role of Ulinastatin, a trypsin inhibitor, in severe acute pancreatitis in critical care setting: A retrospective analysis.
乌司他丁在重症监护室中治疗重症急性胰腺炎的作用：回顾性分析。
J Crit Care. 2018 Jun;45:27-32. doi: 10.1016/j.jcrc.2018.01.021. Epub 2018 Jan 31.
4
Ulinastatin ameliorates tissue damage of severe acute pancreatitis through modulating regulatory T cells.乌司他丁通过调节调节性T细胞改善重症急性胰腺炎的组织损伤。
J Inflamm (Lond). 2017 Mar 20;14:7. doi: 10.1186/s12950-017-0154-7. eCollection 2017.
5
Epidemiology, aetiology and outcomes of acute pancreatitis: A retrospective cohort study.急性胰腺炎的流行病学、病因学和结局：一项回顾性队列研究。
Int J Surg. 2015 Nov;23(Pt A):68-74. doi: 10.1016/j.ijsu.2015.07.701. Epub 2015 Sep 16.
6
Validation of 'moderately severe acute pancreatitis' in patients with acute pancreatitis.急性胰腺炎患者中“中度重症急性胰腺炎”的验证
JNMA J Nepal Med Assoc. 2013 Oct-Dec;52(192):580-5.
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Morphological changes of the pancreas in course of acute pancreatitis during treatment with Ulinastatin.乌司他丁治疗急性胰腺炎过程中胰腺的形态学变化
Pol Przegl Chir. 2013 Mar;85(3):114-22. doi: 10.2478/pjs-2013-0020.
8
Classification of acute pancreatitis--2012: revision of the Atlanta classification and definitions by international consensus.急性胰腺炎的分类-2012：亚特兰大分类修订和国际共识定义。
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Antiproteases in the treatment of acute necrotizing pancreatitis: continuous regional arterial infusion.抗蛋白酶在急性坏死性胰腺炎治疗中的应用：持续区域动脉灌注
JOP. 2007 Jul 9;8(4 Suppl):526-32.
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