Williams Hywel C, McPhee Margaret J, Layfield Carron P
Centre of Evidence Based Dermatology, Lifespan and Population Health, School of Medicine, University of Nottingham, Nottingham, UK.
Clin Exp Dermatol. 2022 Jun;47(6):1048-1059. doi: 10.1111/ced.15140. Epub 2022 Apr 19.
The UK Dermatology Clinical Trials Network (UK DCTN) was formed in 2002 with the aim of developing and supporting high-quality independent national clinical trials that address prioritized research questions for people with skin disease. Its philosophy is to democratize UK dermatological clinical research and to tackle important clinical questions that industry has no incentive to answer. The network also plays a key role in training and capacity development. Its membership of over 1000 individuals includes dermatology consultants, trainees, dermatology nurses, general practitioners, methodologists and patients. Its organizational structures are lean and include a co-ordinating team based at the Centre of Evidence-Based Dermatology in Nottingham, and an executive with independent members to ensure probity and business progression. A prioritization panel and steering group enable a pipeline of projects to be prioritized and refined for external funding from independent sources. The UK DCTN has supported and completed 12 national clinical trials, attracting investment of over £15 million into UK clinical dermatology research. Trials have covered a range of interventions from drugs such as doxycycline (BLISTER), silk clothing for eczema (CLOTHES) and surgical interventions for hidradenitis suppurativa (THESEUS). Trial results are published in prestigious journals and have global impact. Genuine partnership with patients and carers has been a strong feature of the network since its inception. The UK DCTN is proud of its first 20 years of collaborative work, and aims to remain at the forefront of independent dermatological health technology assessment, as well as expanding into areas including diagnostics, artificial intelligence, efficient studies and innovative designs.
英国皮肤病临床试验网络（UK DCTN）成立于2002年，旨在开展并支持高质量的独立国家临床试验，以解决皮肤病患者优先考虑的研究问题。其理念是使英国皮肤病临床研究民主化，并解决行业无意回答的重要临床问题。该网络在培训和能力发展方面也发挥着关键作用。其1000多名成员包括皮肤科顾问、实习生、皮肤科护士、全科医生、方法学家和患者。其组织结构精简，包括位于诺丁汉循证皮肤病中心的协调团队，以及由独立成员组成的执行团队，以确保廉洁和业务推进。一个优先排序小组和指导小组能够对一系列项目进行优先排序和完善，以便从独立来源获得外部资金。UK DCTN已支持并完成了12项国家临床试验，为英国临床皮肤病研究吸引了超过1500万英镑的投资。试验涵盖了一系列干预措施，如多西环素（BLISTER）等药物、用于湿疹的丝绸服装（CLOTHES）以及化脓性汗腺炎的手术干预（THESEUS）。试验结果发表在著名期刊上，并具有全球影响力。自成立以来，与患者和护理人员的真正合作一直是该网络的一大特色。UK DCTN为其头20年的合作工作感到自豪，并旨在保持在独立皮肤病健康技术评估的前沿，同时扩展到包括诊断、人工智能、高效研究和创新设计等领域。
