Liu Yumin, Wang Qiusheng, Liu Xueting, Nakielski Pawel, Pierini Filippo, Li Xiaoran, Yu Jianyong, Ding Bin
Innovation Center for Textile Science and Technology, College of Textiles, Donghua University, Shanghai 201620, China.
Department of Biosystems and Soft Matter, Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw 02-106, Poland.
ACS Appl Bio Mater. 2022 Mar 21;5(3):1047-1056. doi: 10.1021/acsabm.1c01087. Epub 2022 Feb 24.
Adhesive and stretchable nanofibrous hydrogels have attracted extensive attraction in wound dressings, especially for joint wound treatment. However, adhesive hydrogels tend to display poor stretchable behavior. It is still a significant challenge to integrate excellent adhesiveness and stretchability in a nanofibrous hydrogel. Herein, a highly adhesive, stretchable, and breathable nanofibrous hydrogel was developed via an in situ hybrid cross-linking strategy of electrospun nanofibers comprising dopamine (DA) and gelatin methacryloyl (GelMA). Benefiting from the balance of cohesion and adhesion based on photocross-linking of methacryloyl (MA) groups in GelMA and the chemical/physical reaction between GelMA and DA, the nanofibrous hydrogels exhibited tunable adhesive and mechanical properties through varying MA substitution degrees of GelMA. The optimized GelMA60-DA exhibited 2.0 times larger tensile strength (2.4 MPa) with an elongation of about 200%, 2.3 times greater adhesive strength (9.1 kPa) on porcine skin, and 3.1 times higher water vapor transmission rate (10.9 kg m d) compared with gelatin nanofibrous hydrogels. In parallel, the GelMA60-DA nanofibrous hydrogels could facilitate cell growth and accelerate wound healing. This work presented a type of breathable nanofibrous hydrogels with excellent adhesive and stretchable capacities, showing great promise as wound dressings.
粘性和可拉伸的纳米纤维水凝胶在伤口敷料领域引起了广泛关注，特别是用于关节伤口治疗。然而，粘性水凝胶往往表现出较差的可拉伸性能。在纳米纤维水凝胶中整合优异的粘性和可拉伸性仍然是一项重大挑战。在此，通过包含多巴胺（DA）和甲基丙烯酰化明胶（GelMA）的电纺纳米纤维的原位杂化交联策略，开发了一种高粘性、可拉伸且透气的纳米纤维水凝胶。基于GelMA中甲基丙烯酰基（MA）基团的光交联以及GelMA与DA之间的化学/物理反应，纳米纤维水凝胶在内聚力和粘附力之间实现了平衡，通过改变GelMA的MA取代度，其展现出可调节的粘性和机械性能。与明胶纳米纤维水凝胶相比，优化后的GelMA60-DA的拉伸强度提高了2.0倍（2.4 MPa），伸长率约为200%，在猪皮上的粘附强度提高了2.3倍（9.1 kPa），水蒸气透过率提高了3.1倍（10.9 kg m⁻² d⁻¹）。同时，GelMA60-DA纳米纤维水凝胶能够促进细胞生长并加速伤口愈合。这项工作展示了一种具有优异粘性和可拉伸能力的透气纳米纤维水凝胶，作为伤口敷料具有巨大潜力。
