State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Textiles, Donghua University, Shanghai 201620, China.
College of Materials Science and Engineering, Donghua University, Shanghai 201620, China.
ACS Appl Bio Mater. 2021 Apr 19;4(4):3287-3293. doi: 10.1021/acsabm.0c01624. Epub 2021 Mar 15.
Despite the progression in wound treatment, the development of wound dressings with considerable skin regeneration capability and improved patient comfort still faces huge challenges. In this study, a type of asymmetric wettable gradient nanofibrous membrane, which is composed of a hydrophobic polyvinyl butyral (PVB)-polydimethylsiloxane (PDMS) upper layer, a PVB-PDMS/gelatin middle layer, and a hydrophilic gelatin lower layer, has been fabricated. The PVB-PDMS upper layer gave dramatically elevated water contact angles from 71.27° to 125.45° as compared with the gelatin membrane, indicating an asymmetric wettability. The composite membrane exhibited outstanding waterproof capability with a hydrostatic pressure of 58.21 kPa, excellent breathability with a water vapor transmission rate of 8.80 kg m d, improved stretchability and tear resistance, and dramatic improvement in mesenchymal stem cell recruitment with the immobilization of stromal-cell-derived factor-1α for accelerating skin regeneration. The development of asymmetric wettable nanofibrous membranes offers insight into wound-dressing design.
尽管伤口治疗取得了进展，但具有相当皮肤再生能力和改善患者舒适度的伤口敷料的开发仍然面临巨大挑战。在这项研究中，制备了一种不对称润湿性梯度纳米纤维膜，其由疏水性聚丁基乙烯基醚（PVB）-聚二甲基硅氧烷（PDMS）上层、PVB-PDMS/明胶中层和亲水性明胶下层组成。与明胶膜相比，PVB-PDMS 上层赋予了急剧升高的水接触角，从 71.27°增加到 125.45°，表明具有不对称润湿性。复合膜表现出出色的防水能力，静水压力为 58.21 kPa，良好的透气性，水蒸气透过率为 8.80 kg m d，改善了拉伸性和抗撕裂性，并通过固定基质细胞衍生因子-1α（SDF-1α）显著提高间充质干细胞募集，以加速皮肤再生。不对称润湿性纳米纤维膜的开发为伤口敷料设计提供了新的思路。
