• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

海洋来源的氮代谢物对 的异柠檬酸裂解酶的抑制作用。

Inhibitory Effects of Nitrogenous Metabolites from a Marine-Derived on Isocitrate Lyase of .

机构信息

Department of Agricultural Biotechnology, College of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea.

Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Korea.

出版信息

Mar Drugs. 2022 Feb 13;20(2):138. doi: 10.3390/md20020138.

DOI:10.3390/md20020138
PMID:35200667
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8878140/
Abstract

Two nitrogenous metabolites, bacillimide () and bacillapyrrole (), were isolated from the culture broth of the marine-derived actinomycete . Based on the results of combined spectroscopic and chemical analyses, the structure of bacillimide () was determined to be a new cyclopenta[]pyrrole-1,3-dione bearing a methylsulfide group, while the previously reported bacillapyrrole () was fully characterized for the first time as a pyrrole-carboxamide bearing an alkyl sulfoxide side chain. Bacillimide () and bacillapyrrole () exerted moderate (IC = 44.24 μM) and weak (IC = 190.45 μM) inhibitory effects on isocitrate lyase, respectively. Based on the growth phenotype using -deletion mutants and expression analyses, we determined that bacillimide () inhibits the transcriptional level of in under C-carbon-utilizing conditions.

摘要

从海洋来源放线菌中分离到两种含氮代谢物，棒曲霉素（）和棒曲霉素（）。基于综合光谱和化学分析的结果，确定棒曲霉素（）的结构为一种新型的含有甲基硫醚基团的环戊[]吡咯-1,3-二酮，而先前报道的棒曲霉素（）则首次被全称为带有烷基磺酰氧基侧链的吡咯酰胺。棒曲霉素（）和棒曲霉素（）对异柠檬酸裂解酶分别表现出中等（IC = 44.24 μM）和较弱（IC = 190.45 μM）的抑制作用。基于 - 缺失突变体的生长表型和表达分析，我们确定棒曲霉素（）在 C 碳利用条件下抑制中的转录水平。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8db/8878140/81d84276ebfc/marinedrugs-20-00138-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8db/8878140/efa7278a8c64/marinedrugs-20-00138-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8db/8878140/36186cf98d6c/marinedrugs-20-00138-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8db/8878140/2a9e103bc5a7/marinedrugs-20-00138-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8db/8878140/a25a9f15db98/marinedrugs-20-00138-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8db/8878140/1307af8f5ed7/marinedrugs-20-00138-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8db/8878140/81d84276ebfc/marinedrugs-20-00138-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8db/8878140/efa7278a8c64/marinedrugs-20-00138-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8db/8878140/36186cf98d6c/marinedrugs-20-00138-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8db/8878140/2a9e103bc5a7/marinedrugs-20-00138-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8db/8878140/a25a9f15db98/marinedrugs-20-00138-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8db/8878140/1307af8f5ed7/marinedrugs-20-00138-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d8db/8878140/81d84276ebfc/marinedrugs-20-00138-g006.jpg

相似文献

1
Inhibitory Effects of Nitrogenous Metabolites from a Marine-Derived on Isocitrate Lyase of .海洋来源的氮代谢物对 的异柠檬酸裂解酶的抑制作用。
Mar Drugs. 2022 Feb 13;20(2):138. doi: 10.3390/md20020138.
2
Bahamaolide A from the marine-derived Streptomyces sp. CNQ343 inhibits isocitrate lyase in Candida albicans.源自海洋链霉菌属菌株CNQ343的巴哈马内酯A可抑制白色念珠菌中的异柠檬酸裂解酶。
Bioorg Med Chem Lett. 2014 Sep 1;24(17):4291-3. doi: 10.1016/j.bmcl.2014.07.021. Epub 2014 Jul 15.
3
Inhibitory Effects of Diketopiperazines from Marine-Derived on the Isocitrate Lyase of .二酮哌嗪类衍生物对 的异柠檬酸裂解酶的抑制作用。
Molecules. 2019 Jun 4;24(11):2111. doi: 10.3390/molecules24112111.
4
Mohangamides A and B, new dilactone-tethered pseudo-dimeric peptides inhibiting Candida albicans isocitrate lyase.莫杭酰胺 A 和 B，新型二聚体连接的双内酯假二聚肽，抑制白色念珠菌异柠檬酸裂解酶。
Org Lett. 2015 Feb 6;17(3):712-5. doi: 10.1021/ol5037248. Epub 2015 Jan 26.
5
Inhibition of Candida albicans isocitrate lyase activity by cadiolides and synoilides from the ascidian Synoicum sp.抑制白色念珠菌异柠檬酸裂解酶活性的 cadiolides 和 synoilides 来自于尾索动物 Synoicum sp.
Bioorg Med Chem Lett. 2013 Jul 15;23(14):4099-101. doi: 10.1016/j.bmcl.2013.05.051. Epub 2013 May 22.
6
Bahamaolides A and B, antifungal polyene polyol macrolides from the marine actinomycete Streptomyces sp.巴哈马内酯 A 和 B，一种来自海洋放线菌链霉菌的抗真菌多烯多醇大环内酯
J Nat Prod. 2012 May 25;75(5):959-67. doi: 10.1021/np3001915. Epub 2012 May 10.
7
Inhibitory Effects of Epipolythiodioxopiperazine Fungal Metabolites on Isocitrate Lyase in the Glyoxylate Cycle of .表鬼臼毒素二酮哌嗪真菌代谢产物对.乙醛酸循环中异柠檬酸裂解酶的抑制作用。
Mar Drugs. 2021 May 22;19(6):295. doi: 10.3390/md19060295.
8
D319 induced antifungal effects through ROS-mediated apoptosis and inhibited isocitrate lyase in Candida albicans.D319 通过 ROS 介导的细胞凋亡诱导抗真菌作用，并抑制白念珠菌中的异柠檬酸裂解酶。
Biochim Biophys Acta Gen Subj. 2022 Feb;1866(2):130050. doi: 10.1016/j.bbagen.2021.130050. Epub 2021 Nov 18.
9
5-Hydroxyindole-type alkaloids, as Candida albicans isocitrate lyase inhibitors, from the tropical sponge Hyrtios sp.来自热带海绵Hyrtios sp.的5-羟基吲哚型生物碱，作为白色念珠菌异柠檬酸裂解酶抑制剂
Bioorg Med Chem Lett. 2009 Feb 15;19(4):1051-3. doi: 10.1016/j.bmcl.2009.01.017. Epub 2009 Jan 11.
10
Suvanine sesterterpenes from a tropical sponge Coscinoderma sp. inhibit isocitrate lyase in the glyoxylate cycle.来自热带海绵Coscinoderma sp.的苏瓦宁倍半萜抑制乙醛酸循环中的异柠檬酸裂解酶。
Mar Drugs. 2014 Oct 10;12(10):5148-59. doi: 10.3390/md12105148.

引用本文的文献

1
Marine-Derived Metabolites Act as Promising Antifungal Agents.海洋来源代谢产物可作为有前途的抗真菌剂。
Mar Drugs. 2024 Apr 17;22(4):180. doi: 10.3390/md22040180.
2
Marine -Derived Novel Alkaloids Discovered in the Past Decade.过去十年中发现的海洋来源新型生物碱。
Mar Drugs. 2024 Jan 22;22(1):51. doi: 10.3390/md22010051.
3
Integrated Bioinformatics-Based Subtractive Genomics Approach to Decipher the Therapeutic Drug Target and Its Possible Intervention against Brucellosis.基于综合生物信息学的消减基因组学方法来破译治疗药物靶点及其对布鲁氏菌病的可能干预措施。

本文引用的文献

1
Antibacterial Activity and Mode of Action of Lactoquinomycin A from .乳杆菌素 A 的抗菌活性及作用模式研究。
Mar Drugs. 2020 Dec 24;19(1):7. doi: 10.3390/md19010007.
2
Pyrrole: An insight into recent pharmacological advances with structure activity relationship.吡咯：对近年来基于结构活性关系的药理学进展的深入了解。
Eur J Med Chem. 2018 Sep 5;157:527-561. doi: 10.1016/j.ejmech.2018.08.002. Epub 2018 Aug 4.
3
A New Series of Pyrrole-Based Chalcones: Synthesis and Evaluation of Antimicrobial Activity, Cytotoxicity, and Genotoxicity.
Bioengineering (Basel). 2022 Nov 1;9(11):633. doi: 10.3390/bioengineering9110633.
基于吡咯的查耳酮的新系列：抗菌活性、细胞毒性和遗传毒性评价的合成。
Molecules. 2017 Nov 30;22(12):2112. doi: 10.3390/molecules22122112.
4
Identification of new anti-inflammatory agents based on nitrosporeusine natural products of marine origin.基于海洋来源的硝化孢子素天然产物鉴定新型抗炎药物。
Eur J Med Chem. 2017 Jul 28;135:89-109. doi: 10.1016/j.ejmech.2017.04.015. Epub 2017 Apr 13.
5
Pyrrole and Fused Pyrrole Compounds with Bioactivity against Inflammatory Mediators.具有抗炎症介质生物活性的吡咯及稠合吡咯化合物。
Molecules. 2017 Mar 17;22(3):461. doi: 10.3390/molecules22030461.
6
Pyrrole: An emerging scaffold for construction of valuable therapeutic agents.吡咯：构建有价值治疗药物的新兴骨架。
Eur J Med Chem. 2016 Mar 3;110:13-31. doi: 10.1016/j.ejmech.2015.12.017. Epub 2015 Dec 13.
7
Novel antiviral compounds against gastroenteric viral infections.新型抗消化道病毒感染的抗病毒化合物。
Arch Pharm (Weinheim). 2015 Mar;348(3):194-205. doi: 10.1002/ardp.201400387. Epub 2015 Feb 18.
8
New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancer.具有有效微管蛋白聚合抑制活性的新型吡咯衍生物作为抗癌剂，包括依赖刺猬信号通路的癌症。
J Med Chem. 2014 Aug 14;57(15):6531-52. doi: 10.1021/jm500561a. Epub 2014 Jul 29.
9
Nitrosporeusines A and B, unprecedented thioester-bearing alkaloids from the Arctic Streptomyces nitrosporeus.硝基囊孢素 A 和 B，来自北极诺氏链霉菌的前所未有的含硫酯生物碱。
Org Lett. 2013 Oct 18;15(20):5366-9. doi: 10.1021/ol4026809. Epub 2013 Oct 3.
10
Intracellular acetyl unit transport in fungal carbon metabolism.真菌碳代谢中的细胞内乙酰单位转运
Eukaryot Cell. 2010 Dec;9(12):1809-15. doi: 10.1128/EC.00172-10. Epub 2010 Oct 1.