Damar İbrahim Halil, Eroz Recep
Department of Cardiology, Medical Faculty, Duzce University, Duzce 81820, Turkey.
Department of Medical Genetics, Medical Faculty, Aksaray University, Aksaray 68100, Turkey.
J Cardiovasc Dev Dis. 2022 Feb 14;9(2):58. doi: 10.3390/jcdd9020058.
(1) Background: ST-elevation myocardial infarction (STEMI) is an inflammatory disease in which neutrophils, macrophages, and lymphocytes accumulate in the ischemic myocardium and have important functions. Nucleolar-organizing regions (NORs) are the site of the ribosomal genes composed of ribosomal DNA and proteins. We aimed to evaluate AgNOR proteins, which have never been studied in patients with STEMI in the literature. (2) Methods: A total of 140 participants (75 with STEMI and 65 volunteers without any diagnosis of acute coronary syndrome) were included in this study. Echocardiography was carried out, and mean AgNOR number and total AgNOR area/total nuclear area (TAA/TNA) were evaluated for all individuals. (3) Results: The mean AgNOR number and TAA/TNA ratio were significantly higher in the STEMI group than the control ( < 0.001). Statistically significant relations between both TAA/TNA ratio and mean AgNOR number and interventricular septal thickness, fasting blood sugar, creatinine, HDL, hemoglobin (g/dL), WBC (µL/mL), monocytes, neutrophils, and neutrophil/lymphocyte ratio were detected ( < 0.05). Moreover, a statistically significant relation between LDL (mg/dL) and mean AgNOR number ( = 0.005) was detected. (4) Conclusion: Both AgNOR protein amounts increase depending on the hypoxia that occurs in STEMI. The AgNOR proteins may thus be promising markers in STEMI.
（1）背景：ST段抬高型心肌梗死（STEMI）是一种炎症性疾病，其中中性粒细胞、巨噬细胞和淋巴细胞在缺血心肌中积聚并发挥重要作用。核仁组织区（NORs）是由核糖体DNA和蛋白质组成的核糖体基因的位点。我们旨在评估银染核仁组成区相关蛋白（AgNOR），文献中尚未对STEMI患者进行过此类研究。（2）方法：本研究共纳入140名参与者（75例STEMI患者和65名未诊断为急性冠状动脉综合征的志愿者）。进行了超声心动图检查，并评估了所有个体的平均AgNOR数量以及总AgNOR面积/总核面积（TAA/TNA）。（3）结果：STEMI组的平均AgNOR数量和TAA/TNA比值显著高于对照组（<0.001）。检测到TAA/TNA比值和平均AgNOR数量与室间隔厚度、空腹血糖、肌酐、高密度脂蛋白、血红蛋白（g/dL）、白细胞（µL/mL）、单核细胞、中性粒细胞以及中性粒细胞/淋巴细胞比值之间存在统计学显著关系（<0.05）。此外，检测到低密度脂蛋白（mg/dL）与平均AgNOR数量之间存在统计学显著关系（=0.005）。（4）结论：STEMI中发生的缺氧会导致AgNOR蛋白量均增加。因此，AgNOR蛋白可能是STEMI中有前景的标志物。
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