通过多重聚合酶链反应检测诊断的与人类疱疹病毒7型感染相关的前葡萄膜炎：一例报告
Anterior Uveitis Associated with Human Herpesvirus 7 Infection Diagnosed by Multiplex Polymerase Chain Reaction Assay: A Case Report.
作者信息
Shirahama Shintaro, Tanaka Rie, Kaburaki Toshikatsu
机构信息
Department of Ophthalmology, The University of Tokyo Hospital, Tokyo, Japan.
Department of Ophthalmology, Jichi Medical University Saitama Medical Center, Saitama, Japan.
出版信息
Ocul Immunol Inflamm. 2023 Feb;31(2):474-476. doi: 10.1080/09273948.2022.2032191. Epub 2022 Feb 24.
BACKGROUND
Herpetic anterior uveitis (AU) is usually caused by the herpes simplex virus, varicella-zoster virus, and cytomegalovirus. Herein, we report a case of herpetic AU associated with human herpesvirus 7 (HHV-7) infection.
STUDY DESIGN
A case report.
CASE PRESENTATION
A 49-year-old female patient presented with complaints of blurred vision and hyperemia in the right eye. Slit-lamp examination revealed bilateral fine and a few small white keratic precipitates (KPs), Descemet membrane folds in the right eye, and severe and mild cellular infiltration in the anterior chamber of the right and left eye, respectively. HHV-7 viral DNA was detected by a polymerase chain reaction assay of an aqueous humor sample. The AU improved significantly with topical steroids.
CONCLUSION
We report a rare case of herpetic AU characterized by fine and small white KPs in which only HHV-7 DNA was detected in the aqueous humor.
背景
疱疹性前葡萄膜炎（AU）通常由单纯疱疹病毒、水痘-带状疱疹病毒和巨细胞病毒引起。在此，我们报告一例与人类疱疹病毒7（HHV-7）感染相关的疱疹性AU病例。
研究设计
病例报告。
病例介绍
一名49岁女性患者因右眼视物模糊和充血前来就诊。裂隙灯检查发现双侧有细小及少量白色角膜后沉着物（KPs），右眼有Descemet膜皱褶，右眼和左眼前房分别有重度和轻度细胞浸润。通过房水样本的聚合酶链反应检测到HHV-7病毒DNA。局部使用类固醇后，AU明显改善。
结论
我们报告了一例罕见的疱疹性AU病例，其特征为细小白色KPs，且房水中仅检测到HHV-7 DNA。
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