氯巴占的毒理学
Toxicology of clobazam.
作者信息
Schütz E
出版信息
Br J Clin Pharmacol. 1979;7 Suppl 1(Suppl 1):33S-35S. doi: 10.1111/j.1365-2125.1979.tb04662.x.
Abstract
1 Extensive toxicological investigations of clobazam are summarized. 2 LD50 values after oral administration ranged from 100 mg/kg in the dog to 6000 mg/kg in the rat. 3 Long-term repeated dose studies have shown withdrawal effects in the dog and monkey (notably convulsions leading to death), similar to those known to occur with other benzodiazepines. 4 It is concluded that the overall safety and tolerability of clobazam have been demonstrated in the preclinical animal studies.
摘要
- 总结了氯巴占广泛的毒理学研究情况。2. 口服给药后的半数致死量（LD50）值，犬为100毫克/千克，大鼠为6000毫克/千克。3. 长期重复给药研究表明，犬和猴会出现戒断效应（尤其是惊厥致死），与其他苯二氮䓬类药物已知的情况相似。4. 结论是，氯巴占的总体安全性和耐受性在临床前动物研究中已得到证实。
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