氯巴占的毒理学
Toxicology of clobazam.
作者信息
Schütz E
出版信息
Br J Clin Pharmacol. 1979;7 Suppl 1(Suppl 1):33S-35S. doi: 10.1111/j.1365-2125.1979.tb04662.x.
Abstract
1 Extensive toxicological investigations of clobazam are summarized. 2 LD50 values after oral administration ranged from 100 mg/kg in the dog to 6000 mg/kg in the rat. 3 Long-term repeated dose studies have shown withdrawal effects in the dog and monkey (notably convulsions leading to death), similar to those known to occur with other benzodiazepines. 4 It is concluded that the overall safety and tolerability of clobazam have been demonstrated in the preclinical animal studies.
摘要
- 总结了氯巴占广泛的毒理学研究情况。2. 口服给药后的半数致死量（LD50）值，犬为100毫克/千克，大鼠为6000毫克/千克。3. 长期重复给药研究表明，犬和猴会出现戒断效应（尤其是惊厥致死），与其他苯二氮䓬类药物已知的情况相似。4. 结论是，氯巴占的总体安全性和耐受性在临床前动物研究中已得到证实。
相似文献
1
Toxicology of clobazam.氯巴占的毒理学
Br J Clin Pharmacol. 1979;7 Suppl 1(Suppl 1):33S-35S. doi: 10.1111/j.1365-2125.1979.tb04662.x.
2
Toxicological evaluations of the benzodiazepine doxefazepam.苯二氮䓬类药物多西泮的毒理学评估。
Arzneimittelforschung. 1989 Apr;39(4):480-4.
3
Safety aspects of midazolam.咪达唑仑的安全性方面
Br J Clin Pharmacol. 1983;16 Suppl 1(Suppl 1):37S-41S. doi: 10.1111/j.1365-2125.1983.tb02269.x.
4
Preclinical safety evaluation of the benzodiazepine quazepam.苯二氮䓬类药物夸西泮的临床前安全性评价。
Arzneimittelforschung. 1987 Aug;37(8):906-13.
5
Toxicological and teratological studies of azanidazole.
Arzneimittelforschung. 1978;28(12):2251-6.
6
The effect of flunitrazepam on reproduction in the rat. The use of cross-fostering in the evaluation of postnatal parameters in rat reproduction studies.氟硝西泮对大鼠生殖的影响。交叉寄养在大鼠生殖研究产后参数评估中的应用。
Toxicol Appl Pharmacol. 1980 Mar 30;53(1):92-100. doi: 10.1016/0041-008x(80)90385-3.
7
Results of toxicological studies on praziquantel.吡喹酮的毒理学研究结果。
Arzneimittelforschung. 1984;34(9B):1137-44.
8
Toxicological investigations with nimodipine. Summary of relevant studies.尼莫地平的毒理学研究。相关研究综述。
Arzneimittelforschung. 1986 Dec;36(12):1733-5.
9
Toxicological studies on gemfibrozil.吉非贝齐的毒理学研究。
Proc R Soc Med. 1976;69 Suppl 2(Suppl 2):15-23. doi: 10.1177/00359157760690S205.
10
Preclinical toxicologic evaluation of nadolol, a new beta-adrenergic antagonist.新型β-肾上腺素能拮抗剂纳多洛尔的临床前毒理学评估
Toxicol Appl Pharmacol. 1978 May;44(2):379-89. doi: 10.1016/0041-008x(78)90198-9.
引用本文的文献
1
Clobazam: a review of its pharmacological properties and therapeutic use in anxiety.氯巴占：其药理学特性及在焦虑症治疗中的应用综述
Drugs. 1980 Sep;20(3):161-78. doi: 10.2165/00003495-198020030-00001.
2
Clobazam: pharmacological and therapeutic profile.氯巴占：药理作用与治疗概况。
Br J Clin Pharmacol. 1979;7 Suppl 1(Suppl 1):151S-155S. doi: 10.1111/j.1365-2125.1979.tb04685.x.
Zotero 插件