氯巴占：药理作用与治疗概况。
Clobazam: pharmacological and therapeutic profile.
作者信息
Hanks G W
出版信息
Br J Clin Pharmacol. 1979;7 Suppl 1(Suppl 1):151S-155S. doi: 10.1111/j.1365-2125.1979.tb04685.x.
Abstract
1 Clobazam is a 1,5-benzodiazepine the pharmacological profile of which differs from that of the 1,4 benzodiazepines in that it displays a wide separation of psychosedative or 'tranquillizing' properties from impairment of motor coordination. This is associated with a relative lack of muscle relaxant activity. 2 In man it seems to be an effective anxiolytic agent when given in daily doses of 20-30 mg but produces minimal effects on psychomotor performance at these dose levels. 3 Clobazam has a long elimination half-life of about 18 h; the main metabolite is N-desmethylclobazam. Clobazam seems to share the good safety and tolerability characteristics of the 1,4 benzodiazepines.
摘要
- 氯巴占是一种1,5 - 苯二氮䓬类药物，其药理特性与1,4 - 苯二氮䓬类药物不同，在于它在精神镇静或“安定”特性与运动协调受损之间表现出很大差异。这与相对缺乏肌肉松弛活性有关。2. 在人体中，每日服用20 - 30毫克时，它似乎是一种有效的抗焦虑剂，但在这些剂量水平下对精神运动性能产生的影响极小。3. 氯巴占的消除半衰期较长，约为18小时；主要代谢产物是N - 去甲基氯巴占。氯巴占似乎具有1,4 - 苯二氮䓬类药物良好的安全性和耐受性特征。
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